ArticleScience advances2021
PDLLA-Zn-nitrided Fe bioresorbable scaffold with 53-μm-thick metallic struts and tunable multistage biodegradation function.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- First-in-human evaluation of a novel ultrathin sirolimus-eluting iron bioresorbable scaffold: 3-year outcomes of the IBS-FIM trial.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Trial
- Mechanically governed fracture resistance of biodegradable Zn-Cu alloy stents: Role of ring-length optimized structural design.Bioactive materials · 2026Article
- Balloon-expandable trilayer nitrided iron/Zn/poly-D,L-lactic acid metallic tracheal stent: structural characterization, mechanical performance, and short-term safety evaluation in rabbits.Journal of thoracic disease · 2026Article
- Iron-Based Bioresorbable Scaffold in Contemporary: A Viewpoint on Design Rationale, Early Evidence, and Unresolved Questions.JACC. Asia · 2026Article
- Effects of molecular weight, end group of polylactide and coating thickness on corrosion rate and inhomogeneity of iron under biomimetic conditions.Regenerative biomaterials · 2026Article
- Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A thermogalvanic cell dressing for smart wound monitoring and accelerated healing.Nature biomedical engineering · 2026Article
- Zn ion-implanted absorbable Fe for improved cytocompatibility and mitigated neointimal hyperplasia.Regenerative biomaterials · 2026Article
- Development and translation of biodegradable metal stents: from heart to brain.Regenerative biomaterials · 2026Review
- A hierarchical MgFBioactive materials · 2025Article
- Early "Scars" and Long-Term Promise of Bioresorbable Scaffolds: A Decade of Evidence From SCAAR.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Biodegradable Metal-Based Stents: Advances, Challenges, and Prospects.Journal of functional biomaterials · 2025Review
- Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy.Nature communications · 2025Article
- Enhancing radial strength and expansion uniformity of iron-based vascular scaffolds: a numerical and experimental investigation on topological optimization.Frontiers in bioengineering and biotechnology · 2025Article
- Radiopaque FeMnN-Mo composite drawn filled tubing wires for braided absorbable neurovascular devices.Bioactive materials · 2024Article
- Maglev-fabricated long and biodegradable stent for interventional treatment of peripheral vessels.Nature communications · 2024Article
- Long-term efficacy, safety and biocompatibility of a novel sirolimus eluting iron bioresorbable scaffold in a porcine model.Bioactive materials · 2024Article
- Absorbable metal stents for vascular use in pediatric cardiology: progress and outlook.Frontiers in cardiovascular medicine · 2024Review
- Benchtop proof of concept and comparison of iron- and magnesium-based bioresorbable flow diverters.Journal of neurosurgery · 2023Article
- Moving research direction in the field of metallic bioresorbable stents-A mini-review.Bioactive materials · 2023Review
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Balancing the biodegradability and mechanical integrity of a bioresorbable scaffold (BRS) with time after implantation to match the remodeling of the scaffolded blood vessel is important, but a key challenge in doing so remains. This study presents a novel intercalated structure of a metallic BRS by introducing a nanoscale Zn sacrificial layer between the nitrided Fe platform and the sirolimus-carrying poly(d,l-lactide) drug coating. The PDLLA-Zn-FeN BRS shows a multistage biodegradation behavior, maintaining mechanical integrity at the initial stage and exhibiting accelerated biodegradation at the subsequent stage in both rabbit abdominal aortas and human coronary arteries, where complete biodegradation was observed about 2 years after implantation. The presence of the nanoscale Zn sacrificial layer with an adjustable thickness also contributes to the tunable biodegradation of BRS and allows the reduction of the metallic strut thickness to 53 μm, with radial strength as strong as that of the current permanent drug-eluting stents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.