ArticleScience advances2021
The CHD8/CHD7/Kismet family links blood-brain barrier glia and serotonin to ASD-associated sleep defects.
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
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29 citing papers in PubMed, 42 citations in OpenAlex.
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- Current Evidence for Sleep States inCurrent sleep medicine reports · 2026Review
- Gut Microbiotas, Plasma Metabolites, and Autism Spectrum Disorder: A Bidirectional Mendelian Randomization Analysis.Pathogens (Basel, Switzerland) · 2025Article
- Dysregulation of Glial Gap Junction Protein Innexin2 Mediates Seizures and Disrupted Sleep in a Drosophila Model for North Sea Progressive Myoclonus Epilepsy.Journal of neuroscience research · 2025Article
- Molecular profiling of adult C. elegans glia across sexes by single-nuclear RNA-seq.Developmental cell · 2025Article
- Kismet/CHD7/CHD8 affects gut microbiota, mechanics, and the gut-brain axis in Drosophila melanogaster.Biophysical journal · 2025Article
- Circadian activity and sleep architecture in autism spectrum disorder mouse model withFrontiers in sleep · 2025Article
- Association ofJournal of clinical medicine · 2024Article
- Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.Cell reports · 2024Article
- Molecular profiling of the hippocampus of children with autism spectrum disorder.Molecular psychiatry · 2024Article
- Autism spectrum disorders and the gastrointestinal tract: insights into mechanisms and clinical relevance.Nature reviews. Gastroenterology & hepatology · 2024Review
- Orthologs ofSleep advances : a journal of the Sleep Research Society · 2024Article
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- Pleiotropic effects of a high confidence Autism Spectrum Disorder gene,Neurobiology of sleep and circadian rhythms · 2023Article
- Sleep disturbances in autism spectrum disorder: Animal models, neural mechanisms, and therapeutics.Neurobiology of sleep and circadian rhythms · 2023Review
- High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways.Cell reports · 2023Article
- A conserved role forSleep advances : a journal of the Sleep Research Society · 2023Article
Corrections and comments
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Authors and funding
21 authors at 8 institutions in 2 countries.
Mireia Coll-TanéDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, 6525 GA, Nijmegen, Netherlands. mireia.colltane@radboudumc.nl annette.schenck@radboudumc.nl.ORCID 0000-0002-1796-2455
Naihua N GongDepartments of Psychiatry and Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-2107-0166
Samuel J BelferDepartments of Psychiatry and Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-8018-879X
Lara V van RenssenDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, 6525 GA, Nijmegen, Netherlands.ORCID 0000-0002-0772-3688
Evangeline C Kurtz-NelsonDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98185, USA.ORCID 0000-0002-9418-7915
Milan SzuperakDepartments of Psychiatry and Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-7910-2533
Ilse EidhofDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, 6525 GA, Nijmegen, Netherlands.ORCID 0000-0002-1567-3078
Boyd van ReijmersdalDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, 6525 GA, Nijmegen, Netherlands.ORCID 0000-0002-2212-6734
Isabel TerwindtDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, 6525 GA, Nijmegen, Netherlands.ORCID 0000-0002-2944-1681
Jaclyn DurkinDepartments of Psychiatry and Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-0618-626X
Michel M M VerheijDepartment of Cognitive Neuroscience, Centre for Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, Netherlands.
Chang N KimDepartments of Anatomy and Psychiatry, University of California, San Francisco, CA 94143 USA.ORCID 0000-0001-7921-4447
Caitlin M HudacCenter for Youth Development and Intervention and Department of Psychology, University of Alabama, Tuscaloosa, AL 35487, USA.ORCID 0000-0002-0478-440X
Tomasz J NowakowskiDepartments of Anatomy and Psychiatry, University of California, San Francisco, CA 94143 USA.ORCID 0000-0003-2345-4964
Raphael A BernierDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98185, USA.
Sigrid PillenCenter for Sleep Medicine, Kempenhaeghe, Heeze, Netherlands.ORCID 0000-0001-8679-9535
Rachel K EarlDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98185, USA.
Evan E EichlerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.ORCID 0000-0002-8246-4014
Tjitske KleefstraDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, 6525 GA, Nijmegen, Netherlands.
Matthew S KayserDepartments of Psychiatry and Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-2359-4967
Annette SchenckDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, 6525 GA, Nijmegen, Netherlands. mireia.colltane@radboudumc.nl annette.schenck@radboudumc.nl.ORCID 0000-0002-6918-3314
Radboud University Nijmegen · NLUniversity of Pennsylvania · USUniversity of Washington · USUniversity of California, San Francisco · USHoward Hughes Medical Institute · USKempenhaeghe · NLNetherlands Institute for Neuroscience · NLUniversity of Alabama · US
Funding
Training in Sleep & Sleep DisordersT32HL007953 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI David Menassah Raizen, AMY M SAWYER · 2000 to 2026
$10.6MSporadic Mutations and Autism Spectrum DisordersR01MH101221 · NIMH · UNIVERSITY OF WASHINGTON · PI EICHLER, EVAN · 2013 to 2025
$9.2MIntellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI DOHERTY, DANIEL · 2014 to 2019
$7.9MBuilding brains in our sleep: A Drosophila larval platform for examining sleep and neurogenesisDP2NS111996 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KAYSER, MATTHEW S · 2018 to 2018
$2.4MPhenotypic Characterization of Gene Disrupting Mutations in ASDR01MH100047 · NIMH · UNIVERSITY OF WASHINGTON · PI BERNIER, RAPHAEL A · 2014 to 2018
$2.1MA critical period of sleep required for normal brain developmentK08NS090461 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KAYSER, MATTHEW S · 2014 to 2018
$952kA Drosophila Model for Behavioral Sleep Modification in Alzheimer's DiseaseF30AG058409 · NIA · UNIVERSITY OF PENNSYLVANIA · PI BELFER, SAMUEL · 2017 to 2019
$71kNHLBI NIH HHS T32 HL007953NIA NIH HHS F30 AG058409NICHD NIH HHS U54 HD083091NIMH NIH HHS R01 MH100047NIMH NIH HHS R01 MH101221NINDS NIH HHS DP2 NS111996NINDS NIH HHS K08 NS090461
Abstract
Sleep disturbances in autism and neurodevelopmental disorders are common and adversely affect patient's quality of life, yet the underlying mechanisms are understudied. We found that individuals with mutations in
Indexed as
Autistic DisorderDNA-Binding ProteinsAnimalsBlood-Brain BarrierDNA HelicasesDrosophilaNeurogliaQuality of LifeSerotoninSleepTranscription FactorsDNA-Binding ProteinsDNA HelicasesSerotoninTranscription Factors
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