Evidence map›Paper›PMID 34088322›Full record

Trial reportRespiratory research2021

Intralymphatic immunotherapy with tyrosine-adsorbed allergens: a double-blind, placebo-controlled trial.

Hye Jung Park, Sae-Hoon Kim, Yoo Seob Shin, Chul Hwan Park, Eun-Suk Cho, Seung Joon Choi, So Hyun Park, Joo Hyun Jung, Il Gyu Kang, Myoung Seok Lee and 4 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02665754 (The Efficacy and Adverse Effect of Intralymphatic Immunotherapy With Tyrosine S®, Allergen Extract for Immunotherapy, in Patients With Allergic Rhinitis Induced by House Dust Mite, Dog, and Cat Allergen), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02665754 phase1completednot on this map

The Efficacy and Adverse Effect of Intralymphatic Immunotherapy With Tyrosine S®, Allergen Extract for Immunotherapy, in Patients With Allergic Rhinitis Induced by House Dust Mite, Dog, and Cat Allergen

TypeinterventionalSponsorGachon University Gil Medical CenterRan2016 to 2020Enrolled32ConditionsAllergic RhinitisArmsILIT with extract of causal allergen, ILIT with normal saline, Rescue medication for allergic rhinitis
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Review
  8. Immunology of allergen immunotherapy.Immunotherapy advances · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Hye Jung Park *Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Sae-Hoon Kim *Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
Yoo Seob ShinDepartment of Allergy and Clinical Immunology, Ajou University Hospital, Ajou University College of Medicine, Suwon, Republic of Korea.
Chul Hwan ParkDepartment of Radiology and the Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Eun-Suk ChoDepartment of Radiology and the Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Seung Joon ChoiDepartment of Radiology, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
So Hyun ParkDepartment of Radiology, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
Joo Hyun JungDepartment of Otolaryngology-Head and Neck Surgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
Il Gyu KangENT-Over-Flower Clinic, Incheon, Republic of Korea.
Myoung Seok LeeDepartment of Radiology, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.
Dae Woo KimDepartment of Otorhinolaryngology Head and Neck Surgery, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.
Sang Min LeeDivision of Pulmonology and Allergy, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, 21, Namdong-daero 774 beon-gil, Namdong-gu, Incheon, 21565, Republic of Korea. allergy21@hotmail.com.ORCID http://orcid.org/0000-0002-9568-2096
Min-Suk YangDivision of Allergy and Clinical Immunology, Department of Internal Medicine, SMG-SNU Boramae Medical Center, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, Republic of Korea. sangminlee77@naver.com.
Sang Pyo LeeDivision of Pulmonology and Allergy, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, 21, Namdong-daero 774 beon-gil, Namdong-gu, Incheon, 21565, Republic of Korea.
Gachon University · KRSNUH SMG-SNU Boramae Medical Center · KRYonsei University · KRAjou University Hospital · KRIncheon Medical Center · KRSeoul National University Bundang Hospital · KR

Funding

Korea Centers for Disease Control and Prevention A092076Ministry of Education NRF-2015R1D1A1A02061943
6 · The paper itself

Abstract

backgroundMost previous studies used aluminum hydroxide-absorbed allergen extracts in evaluating the potential therapeutic roles of intralymphatic allergen-specific immunotherapy (ILAIT). In this study, we evaluated the therapeutic efficacy and safety of ILAIT with L-tyrosine-adsorbed allergen extracts of Dermatophagoides farinae, D. pteronyssinus, cat, dog, or mixtures thereof, in patients with allergic rhinitis induced by these allergens.

methodsIn this randomized, double-blind, placebo-controlled trial, study subjects received three intralymphatic injections of L-tyrosine-adsorbed allergen extracts (active group) or saline (placebo group) at 4-week intervals.

resultsAlthough ILAIT reduced daily medication use and skin reactivity to HDM and cat allergens at 4 months after treatment, overall symptom score on a visual analog scale (VAS), sinonasal outcome test-20 (SNOT-20), rhinoconjunctivitis quality of life questionnaire (RQLQ), daily symptom score (dSS), daily medication score (dMS), daily symptom medication score (dSMS), nasal reactivity to HDM allergen, and basophil activity to HDM, cat, and dog allergens at 4 months and 1 year after treatment were similar between the treatment and control groups. Intralymphatic injection was more painful than a venous puncture, and pain at the injection site was the most frequent local adverse event (12.8%); dyspnea and wheezing were the most common systemic adverse events (5.3%).

conclusionsILAIT with L-tyrosine-adsorbed allergen extracts does not exhibit profound therapeutic efficacy in allergic rhinitis and can provoke moderate-to-severe systemic reactions and cause pain at the injection site.

trial registrationclinicaltrials.gov: NCT02665754; date of registration: 28 January 2016.

Indexed as

Quality of LifeAdultAnimalsAntigens, DermatophagoidesCatsDesensitization, ImmunologicDogsDouble-Blind MethodFemaleFollow-Up StudiesHumansInjections, IntralymphaticMaleRetrospective StudiesRhinitis, AllergicTreatment OutcomeAntigens, DermatophagoidesTyrosineAdverse eventsAllergen immunotherapyAllergic rhinitisIntralymphatic injectionTreatment efficacy

Identifiers

PMID34088322
PMCPMC8178859
OpenAlexW3165809878

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.