SynthesisHeart & lung : the journal of critical care
The incidence, clinical characteristics, and outcomes of pneumothorax in hospitalized COVID-19 patients: A systematic review.
Synthesis in Heart & lung : the journal of critical care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- COVID 19 and febrile neutropenia: Case report and systematic review.Travel medicine and infectious diseasePooled it
- Article
- Trends and Disparities in Pneumothorax-Related Deaths in the United States Before and During the COVID-19 Pandemic: A CDC WONDER Database Analysis.Public health challenges · 2026Article
- Trends in pneumothorax mortality in England (2004-2023): a population-based observational study.The Lancet regional health. Europe · 2026Article
- Prognostic Implications of Pneumothorax and Pneumomediastinum in COVID-19 Pneumonia: A Cross-Sectional Analysis.The open respiratory medicine journal · 2026Article
- Five-Year Retrospective Analysis of Traumatic and Non-Traumatic Pneumothorax in 2797 Patients.Healthcare (Basel, Switzerland) · 2025Article
- Patients with coronavirus disease 2019 and spontaneous pneumothorax: a propensity-matched, multicentre case-control study.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Rates of PCR Positivity of Pleural Drainage Fluid in COVID-19 Patients: Is It Expected?Life (Basel, Switzerland) · 2024Article
- Unraveling Pneumomediastinum in COVID-19 Patients: Insights from a High-Volume-Center Case-Control Study.Diseases (Basel, Switzerland) · 2024Article
- Impact of pneumothorax on mortality, morbidity, and hospital resource utilization in COVID-19 patients: a propensity matched analysis of nationwide inpatient sample database.BMC pulmonary medicine · 2024Article
- Pneumomediastinum and pneumothorax in coronavirus disease-2019: Description of a case series and a matched cohort study.Heliyon · 2024Article
- Prevalence and patient risk factors for pneumothorax in COVID-19 and in influenza pneumonia: a nationwide comparative analysis.Journal of thoracic disease · 2024Article
- Chest X-ray at Emergency Admission and Potential Association with Barotrauma in Mechanically Ventilated Patients: Experience from the Italian Core of the First Pandemic Peak.Tomography (Ann Arbor, Mich.) · 2023Article
- Delayed diagnosis of Lemierre's syndrome in a patient with severe coronavirus disease 2019: importance of comprehensive oral and neck examination - a case report.BMC infectious diseases · 2023Article
- Severe SARS-CoV-2 Pneumonia and Pneumomediastinum/Pneumothorax: A Prospective Observational Study in an Intermediate Respiratory Care Unit.Journal of intensive care medicine · 2023Observational
- The Effect of Comorbidities and Complications on COVID-19 Mortality: A Detailed Retrospective Study in Western Romania.Journal of personalized medicine · 2023Article
- Non-Ventilated Patients with Spontaneous Pneumothorax or Pneumomediastinum Associated with COVID-19: Three-Year Debriefing across Five Pandemic Waves.Journal of personalized medicine · 2023Article
- Bronchopleural fistula associated persistent pneumothorax in a patient recovering from COVID-19 pneumonia: A case report.Clinical case reports · 2023Article
- Article
- Risk factors of pneumothorax and pneumomediastinum in COVID-19: a matched case-control study.BMC infectious diseases · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPneumothorax has been frequently described as a complication of COVID-19 infections.
objectiveIn this systematic review, we describe the incidence, clinical characteristics, and outcomes of COVID-19-related pneumothorax.
methodsStudies were identified through MEDLINE, Pubmed, and Google Scholar databases using keywords of "COVID-19," "SARS-CoV-2," "pneumothorax," "pneumomediastinum," and "barotrauma" from January 1st, 2020 to January 30th, 2021.
resultsAmong the nine observational studies, the incidence of pneumothorax is low at 0.3% in hospitalized COVID-19 patients. However, the incidence of pneumothorax increases to 12.8-23.8% in those requiring invasive mechanical ventilation (IMV) with a high mortality rate up to 100%. COVID-19-related pneumothorax tends to be unilateral and right-sided. Age, pre-existing lung diseases, and active smoking status are not shown to be risk factors. The time to pneumothorax diagnosis is around 9.0-19.6 days from admission and 5.4 days after IMV initiation. COVID-19-related pneumothoraces are associated with prolonged hospitalization, increased likelihood of ICU admission and death, especially among the elderly.
conclusionCOVID-19-related pneumothorax likely signify greater disease severity. With the high variability of COVID-19-related pneumothorax incidence described, a well-designed study is required to better assess the significance of COVID-19-related pneumothorax.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.