Evidence map›Paper›PMID 34087584›Full record

ArticleBiomaterials2021

An ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies.

Juan Wang, Mehmet H Kural, Jonathan Wu, Katherine L Leiby, Vinayak Mishra, Taras Lysyy, Guangxin Li, Jiesi Luo, Allison Greaney, George Tellides and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. In-culture coronary stenting in anFrontiers in cardiovascular medicine · 2025
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Juan WangDepartment of Anesthesiology, School of Medicine, Yale University, New Haven, CT, 06519, USA.
Mehmet H KuralDepartment of Anesthesiology, School of Medicine, Yale University, New Haven, CT, 06519, USA.
Jonathan WuDepartment of Biomedical Engineering, School of Medicine, Yale University, New Haven, CT, 06519, USA.
Katherine L LeibyDepartment of Biomedical Engineering, School of Medicine, Yale University, New Haven, CT, 06519, USA.
Vinayak MishraDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, 06269, USA.
Taras LysyyDepartment of Surgery, School of Medicine, Yale University, New Haven, CT, 06519, USA.
Guangxin LiDepartment of Surgery, School of Medicine, Yale University, New Haven, CT, 06519, USA.
Jiesi LuoYale Cardiovascular Research Center, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT06519, USA.
Allison GreaneyDepartment of Biomedical Engineering, School of Medicine, Yale University, New Haven, CT, 06519, USA.
George TellidesDepartment of Surgery, School of Medicine, Yale University, New Haven, CT, 06519, USA.
Yibing QyangYale Cardiovascular Research Center, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT06519, USA.
Nan HuangSchool of Material Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, China.
Laura E NiklasonDepartment of Anesthesiology, School of Medicine, Yale University, New Haven, CT, 06519, USA; Department of Biomedical Engineering, School of Medicine, Yale University, New Haven, CT, 06519, USA. Electronic address: laura.niklason@yale.edu.
Yale University · USSouthwest Jiaotong University · CNUniversity of Connecticut · US

Funding

Biologically Selective Drug-Eluting StentR01HL148819 · NHLBI · YALE UNIVERSITY · PI SALTZMAN, WILLIAM · 2019 to 2022
$2.7M
Hyaluronan Coatings for Engineered VesselsR01HL127386 · NHLBI · YALE UNIVERSITY · PI NIKLASON, LAURA E · 2016 to 2019
$2.5M
Engineered Tracheal ReplacementsR01HL138540 · NHLBI · YALE UNIVERSITY · PI NIKLASON, LAURA E · 2017 to 2020
$2.5M
NHLBI NIH HHS R01 HL127386NHLBI NIH HHS R01 HL138540NHLBI NIH HHS R01 HL148819
6 · The paper itself

Abstract

Conventional in vitro methods for biological evaluation of intra-arterial devices such as stents fail to accurately predict cytotoxicity and remodeling events. An ex vivo flow-tunable vascular bioreactor system (VesselBRx), comprising intra- and extra-luminal monitoring capabilities, addresses these limitations. VesselBRx mimics the in vivo physiological, hyperplastic, and cytocompatibility events of absorbable magnesium (Mg)-based stents in ex vivo stent-treated porcine and human coronary arteries, with in-situ and real-time monitoring of local stent degradation effects. Unlike conventional, static cell culture, the VesselBRx perfusion system eliminates unphysiologically high intracellular Mg

Indexed as

Coronary VesselsStentsAbsorbable ImplantsAnimalsHyperplasiaRabbitsSwineTunica IntimaCell apoptosisHyperplasiaLocal microenvironmentMagnesium stentVessel bioreactor

Identifiers

PMID34087584
PMCPMC9195126
OpenAlexW3165199446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.