Evidence map›Paper›PMID 34087515›Full record

ArticleJournal of psychiatric research2021

Depression, health comorbidities, cognitive symptoms and their functional impact: Not just a geriatric problem.

Sophia Miryam Schüssler-Fiorenza Rose, Nicholas T Bott, Erin E Heinemeyer, Nathan C Hantke, Christine E Gould, Rayna B Hirst, Joshua T Jordan, Sherry A Beaudreau, Ruth O'Hara

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Distinct Biotypes of Visual Perception in Major Depressive Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Sophia Miryam Schüssler-Fiorenza RoseDepartment of Genetics, 300 Pasteur Drive, Stanford University School of Medicine, Stanford, CA, 94305, USA. Electronic address: smrose11@stanford.edu.
Nicholas T BottClinical Excellence Research Center, Stanford University School of Medicine, 365 Lasuen St, Stanford, CA, 94305, USA.
Erin E HeinemeyerPGSP-Stanford PsyD Consortium, Palo Alto University, 1791 Arastradero Rd, Palo Alto, CA, 94304, USA.
Nathan C HantkeSierra Pacific Mental Illness Research Education and Clinical Centers (MIRECC), Veterans Affairs Palo Alto Health Care System, 3801 Miranda Ave, Palo Alto, CA, 94304, USA; Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA.
Christine E GouldDepartment of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA, 94305, USA; Geriatric Research Education and Clinical Center (GRECC), Veterans Affairs Palo Alto Health Care System, 3801 Miranda Ave, Palo Alto, CA, 94304, USA.
Rayna B HirstSchool of Psychology, Palo Alto University, 1791 Arastradero Road, Palo Alto, CA, 94304, USA.
Joshua T JordanDepartment of Psychology, Domincan University of California, 50 Acacia Avenue, San Rafael, CA, 94901, USA.
Sherry A BeaudreauSierra Pacific Mental Illness Research Education and Clinical Centers (MIRECC), Veterans Affairs Palo Alto Health Care System, 3801 Miranda Ave, Palo Alto, CA, 94304, USA; Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA, 94305, USA; School of Psychology, University of Queensland, Brisbane, QLD, 4072, Australia.
Ruth O'HaraSierra Pacific Mental Illness Research Education and Clinical Centers (MIRECC), Veterans Affairs Palo Alto Health Care System, 3801 Miranda Ave, Palo Alto, CA, 94304, USA; Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA, 94305, USA; School of Psychology, University of Queensland, Brisbane, QLD, 4072, Australia.
Mental Illness Research, Education and Clinical Centers · USPalo Alto University · USStanford University · USDominican University of California · USGeriatric Research Education and Clinical Center · US

Funding

Integrating the Exposome into Longitudinal Multiomics ProfilingK08ES028825 · NIEHS · STANFORD UNIVERSITY · PI ROSE, SOPHIA MIRYAM SCHÜSSLER-FIORENZA · 2018 to 2022
$1.0M
NIEHS NIH HHS K08 ES028825
6 · The paper itself

Abstract

objectiveTo compare the prevalence of cognitive symptoms and their functional impact by age group accounting for depression and number of other health conditions.

methodsWe analyzed data from the 2011 Behavioral Risk Factor Surveillance System, a population-based, cross-sectional telephone survey of US adults. Twenty-one US states asked participants (n = 131, 273) about cognitive symptoms (worsening confusion or memory loss in the past year) and their functional impact (interference with activities and need for assistance). We analyzed the association between age, depression history and cognitive symptoms and their functional impact using logistic regression and adjusted for demographic characteristics and other health condition count.

resultsThere was a significant interaction between age and depression (p < 0.0001). In adults reporting depression, the adjusted odds of cognitive symptoms in younger age groups (<75 years) were comparable or greater to those in the oldest age group (≥75 years) with a peak in the middle age (45-54 years) group (OR 1.9 (95% Confidence Interval: 1.4-2.5). In adults without depression, adults <75 years had a significantly lower adjusted odds of cognitive symptoms compared to the oldest age group with the exception of the middle-aged group where the difference was not statistically significant. Over half of adults under age 65 with depression reported that cognitive symptoms interfered with life activities compared to 35.7% of adults ≥65 years.

conclusionsCognitive symptoms are not universally higher in older adults; middle-aged adults are also particularly vulnerable. Given the adverse functional impact associated with cognitive symptoms in younger adults, clinicians should assess cognitive symptoms and their functional impact in adults of all ages and consider treatments that impact both cognition and functional domains.

Indexed as

CognitionDepressionAgedBehavioral Risk Factor Surveillance SystemCross-Sectional StudiesHumansMiddle AgedPrevalenceAgeBehavioral risk factor surveillance system (BRFSS)Cognitive symptomsComorbid health conditionsDepressionFunctional impact

Identifiers

PMID34087515
PMCPMC8253546
OpenAlexW3161861605

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.