Evidence map›Paper›PMID 34087312›Full record

ArticleUrology2021

Characterizing the Spectrum of Bladder Health and Lower Urinary Tract Symptoms (LUTS) Among Women: Results From the CARDIA Study.

Alayne D Markland, Liang Shan, Sonya S Brady, Pamela J Schreiner, Stephen Sidney, Stephen K Van Den Eeden, Cora E Lewis

Abstract read
In one paragraph

Article in Urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Subjective social standing and lower urinary tract symptoms among Black and White women and men in four regions of the United States.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alayne D MarklandBirmingham/Atlanta Geriatric Research, Education, and Clinical Center (GRECC), Department of Veterans Affairs, Birmingham, AL; University of Alabama at Birmingham, School of Medicine, Department of Medicine. Electronic address: amarkland@uabmc.edu.
Liang ShanUniversity of Alabama at Birmingham, School of Medicine, Department of Medicine.
Sonya S BradyUniversity of Minnesota, School of Public Health, Division of Epidemiology & Community Health, Minneapolis, MN.
Pamela J SchreinerUniversity of Minnesota, School of Public Health, Division of Epidemiology & Community Health, Minneapolis, MN.
Stephen SidneyDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Stephen K Van Den EedenDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Cora E LewisSchool of Public Health, Birmingham, AL.

Funding

CARDIA-PLUS: A Life Course Investigation of Biopsychosocial Pathways to Bladder Health and Lower Urinary Tract SymptomsR01DK125274 · NIDDK · UNIVERSITY OF MINNESOTA · PI BRADY, SONYA S, MARKLAND, ALAYNE DENISE · 2021 to 2024
$2.5M
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INIDDK NIH HHS R01 DK125274
6 · The paper itself

Abstract

objectivesTo operationalize a new definition for bladder health, we examined the distribution of lower urinary tract symptoms (LUTS) and impact, along with associated factors, among women in the Coronary Artery Risk Development in Young Adults (CARDIA) study.

methodsWe performed cluster analyses using validated LUTS symptom burden and impact scales collected between 2005-2006 and 2010-2011. We performed multinomial logistic regression analyses to evaluate cardiovascular factors (metabolic syndrome, cardiovascular health behaviors, and inflammation) between clusters after adjusting for covariates (demographic, obstetric/gynecologic, co-morbidities).

resultsAmong CARDIA women (median age 51, range 42-59) with complete LUTS data (n = 1302), we identified and compared 4 cluster groups: women who reported no or very mild symptoms and no impact on well-being (bladder health, 44%, n = 569), versus women with LUTS and negative impact on well-being ranging from mild (31%, n = 407), moderate (20%, n = 259), to severe (5%, n = 67). With each 1-point lower BMI (kg/m

conclusionTwo out of 5 midlife women met our definition of bladder health. Bladder health and cardiovascular health among women may share common factors, including lower BMI and the absence of metabolic syndrome.

Indexed as

Health BehaviorHealth StatusAdultBody Mass IndexCluster AnalysisC-Reactive ProteinFemaleHealth SurveysHumansInflammationLongitudinal StudiesLower Urinary Tract SymptomsMetabolic SyndromeMiddle AgedRisk FactorsSeverity of Illness IndexC-Reactive Protein

Identifiers

PMID34087312
PMCPMC9060156

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.