Evidence map›Paper›PMID 34087047›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Origin of the α-Effect in S

Thomas Hansen, Pascal Vermeeren, F Matthias Bickelhaupt, Trevor A Hamlin

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Understanding the SChemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  3. Article
  4. Article
  5. Solvent-induced dual nucleophiles and the α-effect in the SPhysical chemistry chemical physics : PCCP · 2024
    Article
  6. Effects of Methyl Substitution and Leaving Group on E2/SMolecules (Basel, Switzerland) · 2023
    Article
  7. Rational design of iron catalysts for C-X bond activation.Journal of computational chemistry · 2023
    Article
  8. ηChemistry, an Asian journal · 2023
    Article
  9. Rational Tuning of the Reactivity of Three-Membered Heterocycle Ring Openings via SChemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  10. Article
  11. C-X Bond Activation by Palladium: Steric Shielding versus Steric Attraction.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  12. SThe Journal of organic chemistry · 2022
    Article
  13. C(spChemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  14. How Solvation Influences the SThe Journal of organic chemistry · 2022
    Article
  15. Origin of asynchronicity in Diels-Alder reactions.Physical chemistry chemical physics : PCCP · 2021
    Article
  16. Origin of the α-Effect in SAngewandte Chemie (International ed. in English) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Thomas HansenDepartment of Theoretical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-6291-1569
Pascal VermeerenDepartment of Theoretical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2100-6837
F Matthias BickelhauptDepartment of Theoretical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4655-7747
Trevor A HamlinDepartment of Theoretical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Amsterdam Center for Multiscale Modeling (ACMM), Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-5128-1004

Funding

Dutch Astrochemistry Network (DAN)Netherlands Organization for Scientific Research (NWO)
6 · The paper itself

Abstract

The α-effect is a term used to explain the dramatically enhanced reactivity of α-nucleophiles (R-Y-X:

Indexed as

activation strain modelbasicitydensity functional calculationsnucleophilicityα-effect

Identifiers

PMID34087047
PMCPMC8518820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.