ArticleHuman brain mapping2021
Motor and higher-order functions topography of the human dentate nuclei identified with tractography and clustering methods.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- An anatomical and connectivity atlas of the tree shrew brain to bridge rodent and primate neuroanatomy.PLoS biology · 2026Article
- Detailed Mapping of the Cerebellar Dentate Nucleus Using Ultra-High Field (7T) Susceptibility-Weighted Imaging.Cerebellum (London, England) · 2025Article
- Optimizing selectivity of the Cerebellar Cognitive Affective Syndrome Scale by use of correction formulas, and validation of its German version.Journal of neurology · 2025Article
- Subtypes of cognitive impairment in cerebellar disease identified by cross-diagnostic cluster-analysis: results from a German multicenter study.Journal of neurology · 2024Article
- A Virtual In Vivo Dissection and Analysis of Socioaffective Symptoms Related to Cerebellum-Midbrain Reward Circuitry in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Deep multimodal saliency parcellation of cerebellar pathways: Linking microstructure and individual function through explainable multitask learning.Human brain mapping · 2024Article
- AnbioRxiv : the preprint server for biology · 2024Article
- Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity.Communications biology · 2024Article
- Language and the Cerebellum: Structural Connectivity to the Eloquent Brain.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Cognitive-Affective Functions of the Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Resting-state functional connectivity-based parcellation of the human dentate nucleus: new findings and clinical relevance.Brain structure & function · 2023Review
- Abnormal cerebellum connectivity patterns related to motor subtypes of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Cerebellar contributions to fear-based emotional processing: relevance to understanding the neural circuits involved in autism.Frontiers in systems neuroscience · 2023Review
- Parallel processing relies on a distributed, low-dimensional cortico-cerebellar architecture.Network neuroscience (Cambridge, Mass.) · 2023Article
- The CCAS-scale in hereditary ataxias: helpful on the group level, particularly in SCA3, but limited in individual patients.Journal of neurology · 2022Article
- The Cerebellar Involvement in Autism Spectrum Disorders: From the Social Brain to Mouse Models.International journal of molecular sciences · 2022Review
- Computational models of neurotransmission at cerebellar synapses unveil the impact on network computation.Frontiers in computational neuroscience · 2022Review
- Value of Magnetic Resonance Images and Magnetic Resonance Spectroscopy in Diagnosis of Brain Tumors under Fuzzy C-Means Algorithm.Contrast media & molecular imaging · 2022Article
- Motor and higher-order functions topography of the human dentate nuclei identified with tractography and clustering methods.Human brain mapping · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Deep gray matter nuclei are the synaptic relays, responsible to route signals between specific brain areas. Dentate nuclei (DNs) represent the main output channel of the cerebellum and yet are often unexplored especially in humans. We developed a multimodal MRI approach to identify DNs topography on the basis of their connectivity as well as their microstructural features. Based on results, we defined DN parcellations deputed to motor and to higher-order functions in humans in vivo. Whole-brain probabilistic tractography was performed on 25 healthy subjects from the Human Connectome Project to infer DN parcellations based on their connectivity with either the cerebral or the cerebellar cortex, in turn. A third DN atlas was created inputting microstructural diffusion-derived metrics in an unsupervised fuzzy c-means classification algorithm. All analyses were performed in native space, with probability atlas maps generated in standard space. Cerebellar lobule-specific connectivity identified one motor parcellation, accounting for about 30% of the DN volume, and two non-motor parcellations, one cognitive and one sensory, which occupied the remaining volume. The other two approaches provided overlapping results in terms of geometrical distribution with those identified with cerebellar lobule-specific connectivity, although with some differences in volumes. A gender effect was observed with respect to motor areas and higher-order function representations. This is the first study that indicates that more than half of the DN volumes is involved in non-motor functions and that connectivity-based and microstructure-based atlases provide complementary information. These results represent a step-ahead for the interpretation of pathological conditions involving cerebro-cerebellar circuits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.