ArticlePloS one2021
Industrialization as a source of heavy metals and antibiotics which can enhance the antibiotic resistance in wastewater, sewage sludge and river water.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.
- An Overview of Antibiotic Resistance and Abiotic Stresses Affecting Antimicrobial Resistance in Agricultural Soils.International journal of environmental research and public health · 2022Pooled it
- Effect of alkaline pretreatment on cephalosporin degradation and microbial susceptibility in wastewater of cephalosporin drug manufacturing plant.Scientific reports · 2026Article
- Silica Nanoparticles Block Natural Genetic Transformation inACS omega · 2025Article
- The surveillance of antimicrobial resistance in wastewater from a one health perspective: A global scoping and temporal review (2014-2024).One health (Amsterdam, Netherlands) · 2025Article
- Transformations in river water chemistry following wastewater treatment implementation in a mountain region of the Polish Carpathians.Environmental science and pollution research international · 2025Article
- The Microbial Trojan Horse and Antimicrobial Resistance: Acanthamoeba as an Environmental Reservoir for Multidrug Resistant Bacteria.Environmental microbiology · 2025Article
- Factors Affecting Distribution of Pharmaceutically Active Compounds in Bottom Sediments of Odra River Estuary (SW Baltic Sea).Molecules (Basel, Switzerland) · 2025Article
- Importance of wastewater-based and environmental surveillance for monitoring resistance to next-generation antibiotics.Future microbiology · 2025Article
- Individual and Simultaneous Photodegradation of Trimethoprim and Sulfamethoxazole Assessed with the Microbial Assay for Risk Assessment.Molecules (Basel, Switzerland) · 2025Article
- Harnessing CRISPR interference to resensitize laboratory strains and clinical isolates to last resort antibiotics.Scientific reports · 2025Article
- Environmental concentrations of copper and iron can alter the evolution of antimicrobial resistance ofFrontiers in microbiology · 2025Article
- Unlocking Cd(II) biosorption potential of Candida tropicalis XTA 1874 for sustainable wastewater treatment.Scientific reports · 2024Article
- Unravelling the mechanisms of antibiotic and heavy metal resistance co-selection in environmental bacteria.FEMS microbiology reviews · 2024Review
- Non-Canonical Aspects of Antibiotics and Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2024Review
- An overview of the occurrence, impact of process parameters, and the fate of antibiotic resistance genes during anaerobic digestion processes.Environmental science and pollution research international · 2024Review
- Evidence of elevated heavy metals concentrations in wild and farmed sugar kelp (Saccharina latissima) in New England.Scientific reports · 2023Article
- Draft genome analysis forFrontiers in bioengineering and biotechnology · 2023Article
- Developing erythromycin resistance gene by heavy metals, Pb, Zn, and Co, in aquatic ecosystems.Scientific reports · 2022Article
- Heavy Metal (Arsenic) Induced Antibiotic Resistance among Extended-Spectrum β-Lactamase (ESBL) Producing Bacteria of Nosocomial Origin.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Metagenomic analysis of wastewater phageome from a University Hospital in Turkey.Archives of microbiology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spread of antibiotic resistance is closely related with selective pressure in the environment. Wastewater from industrialized regions is characterized by higher concentrations of these pollutants than sewage from less industrialized areas. The aim of this study was to compare the concentrations of contaminants such as antibiotics and heavy metals (HMs), and to evaluate their impact on the spread of genes encoding resistance to antimicrobial drugs in samples of wastewater, sewage sludge and river water in two regions with different levels of industrialization. The factors exerting selective pressure, which significantly contributed to the occurrence of the examined antibiotic resistance genes (ARGs), were identified. The concentrations of selected gene copy numbers conferring resistance to four groups of antibiotics as well as class 1 and 2 integron-integrase genes were determined in the analyzed samples. The concentrations of six HMs and antibiotics corresponding to genes mediated resistance from 3 classes were determined. Based on network analysis, only some of the analyzed antibiotics correlated with ARGs, while HM levels were correlated with ARG concentrations, which can confirm the important role of HMs in promoting drug resistance. The samples from a wastewater treatment plant (WWTP) located an industrialized region were characterized by higher HM contamination and a higher number of significant correlations between the analyzed variables than the samples collected from a WWTP located in a less industrialized region. These results indicated that treated wastewater released into the natural environment can pose a continuous threat to human health by transferring ARGs, antibiotics and HMs to the environment. These findings shed light on the impact of industrialization on antibiotic resistance dissemination.
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Registered trials
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