ArticlePloS one2021
Inferring spikes from calcium imaging in dopamine neurons.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- α-Synuclein pathology differentially alters T-type calcium currents in vulnerable and resilient substantia nigra dopaminergic subpopulations.bioRxiv : the preprint server for biology · 2026Article
- Neural circuit models for evidence accumulation through choice-selective sequences.Nature communications · 2026Article
- Article
- Estrogen modulates reward prediction errors and reinforcement learning.Nature neuroscience · 2025Article
- 5-HTMolecular psychiatry · 2025Article
- Sensitive dLight3 for imaging broad-spectrum dopamine events across brain regions.Research square · 2025Article
- Flexible updating of reward and punishment contingencies by VTA GABA neurons.Current biology : CB · 2025Article
- Chronic in vivo sequelae of repetitive acute mfb-DBS on accumbal dopamine and midbrain neuronal activity.Journal of neurochemistry · 2025Article
- Natural phasic inhibition of dopamine neurons signals cognitive rigidity.bioRxiv : the preprint server for biology · 2024Article
- Elevated parkinsonism pathological markers in dopaminergic neurons with developmental exposure to atrazine.The Science of the total environment · 2024Article
- Review
- Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening.Communications biology · 2023Article
- Artificial Vision: The High-Frequency Electrical Stimulation of the Blind Mouse Retina Decay Spike Generation and Electrogenically Clamped Intracellular CaBioengineering (Basel, Switzerland) · 2023Article
- Network models to enhance the translational impact of cross-species studies.Nature reviews. Neuroscience · 2023Review
- Quantifying uncertainty in spikes estimated from calcium imaging data.Biostatistics (Oxford, England) · 2023Article
- Arginine-vasopressin-expressing neurons in the murine suprachiasmatic nucleus exhibit a circadian rhythm in network coherence in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mesoaccumbal Dopamine Heterogeneity: What Do Dopamine Firing and Release Have to Do with It?Annual review of neuroscience · 2022Review
- Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes.Cell reports · 2022Article
- Local accumbens in vivo imaging during deep brain stimulation reveals a strategy-dependent amelioration of hedonic feeding.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Calcium imaging has led to discoveries about neural correlates of behavior in subcortical neurons, including dopamine (DA) neurons. However, spike inference methods have not been tested in most populations of subcortical neurons. To address this gap, we simultaneously performed calcium imaging and electrophysiology in DA neurons in brain slices and applied a recently developed spike inference algorithm to the GCaMP fluorescence. This revealed that individual spikes can be inferred accurately in this population. Next, we inferred spikes in vivo from calcium imaging from these neurons during Pavlovian conditioning, as well as during navigation in virtual reality. In both cases, we quantitatively recapitulated previous in vivo electrophysiological observations. Our work provides a validated approach to infer spikes from calcium imaging in DA neurons and implies that aspects of both tonic and phasic spike patterns can be recovered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.