ReviewAmerican journal of respiratory and critical care medicine2021
Oxygen Toxicity in Critically Ill Adults.
Review in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06501118 (Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients), which is not on this map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
Who cites it
44 citing papers in PubMed, 84 citations in OpenAlex.
- Protective mechanical ventilation controlled by the real-time mechanical power measurement.Journal of clinical monitoring and computing · 2026Trial
- Investigation of the Acute Effects of Two Different Preoxygenation Methods on Neurodegenerative Biomarkers in Laparoscopic Cholecystectomy Surgery.Medicina (Kaunas, Lithuania) · 2025Trial
- Balancing lung and brain: physiological strategies for ARDS management in acute brain injury.Intensive care medicine · 2026Review
- Beyond routine: evidence and uncertainty in intraoperative oxygen titration.Journal of anesthesia · 2026Article
- Bench evidence, bedside uncertainty: hyperoxia, mechanical ventilation and lung injury.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Article
- Review
- Effects of different preoxygenation strategies on dynamic thiol-disulfide homeostasis and blood gas parameters in patients undergoing laparoscopic cholecystectomy.Perioperative medicine (London, England) · 2026Article
- Precision Oxygen Therapy in the Intensive Care Unit: Matching Oxygen Exposure to Patient Phenotypes.Journal of personalized medicine · 2026Article
- Partial pressure of oxygen, hyperoxemia and hyperoxia in the intensive care or anesthesia setting.Medical gas research · 2026Review
- STOP algorithm for bedside mechanical ventilation: Standardized, evidence-based management of critically ill patients.Biomolecules & biomedicine · 2026Article
- Continuous non-invasive measurement of tidal volume and minute ventilation using a smart nasal cannula.Critical care (London, England) · 2025Article
- Temporal dimensions of oxygen saturation exposure and clinical outcomes in critically ill patients: a retrospective multi-database cohort study.Critical care (London, England) · 2025Article
- Clinical Audit of Acute Oxygen Therapy: Enhancing Patient Care at Dammar Teaching Hospital.Cureus · 2025Article
- Article
- Article
- Development and validation of a hypoxemia prediction model in middle-aged and elderly outpatients undergoing painless gastroscopy.Scientific reports · 2025Article
- Mechanisms of impaired alveolar fluid clearance.Anatomical record (Hoboken, N.J. : 2007) · 2025Review
- Article
- A high fraction of inspired oxygen does not mitigate atelectasis-induced lung tissue hypoxia or injury in experimental acute respiratory distress syndrome.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Oxygen supplementation is one of the most common interventions in critically ill patients. Despite over a century of data suggesting both beneficial and detrimental effects of supplemental oxygen, optimal arterial oxygenation targets in adult patients remain unclear. Laboratory animal studies have consistently showed that exposure to a high Fi
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.