Evidence map›Paper›PMID 34086483›Full record

ArticleThe American journal of psychiatry2021

A Longitudinal Study of Resting-State Connectivity and Response to Psychostimulant Treatment in ADHD.

Luke J Norman, Gustavo Sudre, Marine Bouyssi-Kobar, Wendy Sharp, Philip Shaw

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. From rest to focus: pharmacological modulation of the relationship between resting state dorsal attention network dynamics and task-based brain activation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  17. Evidence from "big data" for the default-mode hypothesis of ADHD: a mega-analysis of multiple large samples.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Luke J NormanSection on Neurobehavioral and Clinical Research, Social and Behavioral Research Branch, National Human Genome Research Institute, NIH, Bethesda, Md. (Norman, Sudre, Bouyssi-Kobar, Sharp, Shaw); Office of the Clinical Director, NIMH, Bethesda, Md. (Sharp, Shaw).
Gustavo SudreSection on Neurobehavioral and Clinical Research, Social and Behavioral Research Branch, National Human Genome Research Institute, NIH, Bethesda, Md. (Norman, Sudre, Bouyssi-Kobar, Sharp, Shaw); Office of the Clinical Director, NIMH, Bethesda, Md. (Sharp, Shaw).
Marine Bouyssi-KobarSection on Neurobehavioral and Clinical Research, Social and Behavioral Research Branch, National Human Genome Research Institute, NIH, Bethesda, Md. (Norman, Sudre, Bouyssi-Kobar, Sharp, Shaw); Office of the Clinical Director, NIMH, Bethesda, Md. (Sharp, Shaw).
Wendy SharpSection on Neurobehavioral and Clinical Research, Social and Behavioral Research Branch, National Human Genome Research Institute, NIH, Bethesda, Md. (Norman, Sudre, Bouyssi-Kobar, Sharp, Shaw); Office of the Clinical Director, NIMH, Bethesda, Md. (Sharp, Shaw).
Philip ShawSection on Neurobehavioral and Clinical Research, Social and Behavioral Research Branch, National Human Genome Research Institute, NIH, Bethesda, Md. (Norman, Sudre, Bouyssi-Kobar, Sharp, Shaw); Office of the Clinical Director, NIMH, Bethesda, Md. (Sharp, Shaw).
National Human Genome Research Institute · US

Funding

The neurobehavioral, environmental and genetic factors impacting ADHD.ZIAHG200378 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI SHAW, PHILIP · 2012 to 2025
$17.7M
Intramural NIH HHS ZIA HG200378
6 · The paper itself

Abstract

objectivePsychostimulants are first-line pharmacological treatments for attention deficit hyperactivity disorder (ADHD), although symptom reduction varies widely between patients and these individual differences in treatment response are poorly understood. The authors sought to examine whether the resting-state functional connectivity within and between cingulo-opercular, striato-thalamic, and default mode networks was associated with treatment response to psychostimulant medication, and whether this relationship changed with development.

methodsPatients with ADHD (N=110; 196 observations; mean age at first observation, 10.83 years, SD=2.2) and typically developing control subjects (N=142; 330 observations; mean age at first observation, 10.49 years, SD=2.81) underwent functional neuroimaging on up to five occasions during development (age range, 6-17 years). For patients, symptoms were assessed on and off psychostimulant medication (methylphenidate-based treatments: N=132 observations, 67%; amphetamine-based treatments: N=64 observations, 33%) using the Diagnostic Interview for Children and Adolescents for parents. Linear mixed-effects models examined whether resting-state connectivity was associated with treatment response and its interaction with age. Comparisons with typically developing control subjects were performed to contextualize any significant associations.

resultsResting-state connectivity within the cingulo-opercular network was associated with a significant interaction between treatment response and age. Specifically, worse responses to treatment compared with better responses to treatment among patients and compared with typically developing control subjects were associated with an atypical increase in cingulo-opercular connectivity with increasing age from childhood to adolescence.

conclusionsThis work delineates how resting-state connectivity may be associated over development with response to psychostimulants in ADHD. Functioning and development within the cingulo-opercular network may warrant further investigation as a contributor to differential response to psychostimulants.

Indexed as

AdolescentAmphetamineAttention Deficit Disorder with HyperactivityBrainCase-Control StudiesCentral Nervous System StimulantsChildFemaleFunctional NeuroimagingHumansInterview, PsychologicalLongitudinal StudiesMagnetic Resonance ImagingMaleMethylphenidateNeural PathwaysAmphetamineCentral Nervous System StimulantsMethylphenidateAttention Deficit Hyperactivity Disorder (ADHD)Cingulo-Opercular NetworkCognitive NeuroscienceNeurodevelopmental DisordersPsychostimulantsResting-State Connectivity

Identifiers

PMID34086483
PMCPMC8528221
OpenAlexW3164448847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.