Evidence map›Paper›PMID 34086156›Full record

ArticleMolecular diversity2022

Rapid synthetic approaches to libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones and 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones.

Roman N Vydzhak, Svitlana Ya Panchishin, Maryna V Kachaeva, Stepan G Pilyo, Viktoriia S Moskvina, Olga V Shablykina, Andriy V Kozytskiy, Volodymyr S Brovarets

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Article in Molecular diversity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Roman N VydzhakV.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St, Kyiv, 02094, Ukraine.
Svitlana Ya PanchishinV.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St, Kyiv, 02094, Ukraine.
Maryna V KachaevaV.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St, Kyiv, 02094, Ukraine.
Stepan G PilyoV.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St, Kyiv, 02094, Ukraine.
Viktoriia S MoskvinaV.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St, Kyiv, 02094, Ukraine. v.moskvina@gmail.com.
Olga V ShablykinaV.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St, Kyiv, 02094, Ukraine.
Andriy V KozytskiyL. V. Pisarzhevskii Institute of Physical Chemistry of the NAS of Ukraine, 31 Nauky Ave, Kyiv, 03028, Ukraine.
Volodymyr S BrovaretsV.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St, Kyiv, 02094, Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An efficient and practical synthetic procedure for libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones using a multicomponent process is presented. A convenient synthetic procedure for obtaining functionalized 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones via ring-opening strategy has also been developed. This protocol was found to be compatible with a wide range of substituents and paves the way for the practical synthesis of title compounds with a broad range of substituents under mild condition. The products can be easily isolated by crystallization without the use of chromatography.

Indexed as

PyrrolesMolecular StructurePyrrolesChromeno[2,3-c]pyrrolesCombinatorial libraryDihydrochromeno[2,3-c]pyrrole-3,9-dionesDihydropyrrolo[3,4-c]pyrazol-6(1H)-onesMulticomponent cyclization

Identifiers

PMID34086156
PMCPMC8175933

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.