Evidence map›Paper›PMID 34086087›Full record

Trial reportInternational journal of colorectal disease2021

Long-term outcomes of Hartmann's procedure versus primary anastomosis for generalized peritonitis due to perforated diverticulitis: follow-up of a prospective multicenter randomized trial (DIVERTI).

M Loire, V Bridoux, D Mege, M Mathonnet, F Mauvais, C Massonnaud, J M Regimbeau, J J Tuech

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of colorectal disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Contemporary management of diverticulitis.Surgery open science · 2024
    Article
  12. Diverticulitis, surgery, evidence-based medicine, and the Steve Jobs' dots: a narrative review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Review
  13. Review
  14. Anastomotic Considerations in Diverticulitis.Clinics in colon and rectal surgery · 2023
    Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

M LoireDepartment of Digestive Surgery, Rouen University Hospital, 76000, Rouen Cedex, France.
V BridouxDepartment of Digestive Surgery, Rouen University Hospital, 76000, Rouen Cedex, France.
D MegeDepartment of Digestive Surgery, Marseille University Hospital La Timone, Marseille, France.
M MathonnetDepartment of Digestive Surgery, Limoges University Hospital, Limoges, France.
F MauvaisDepartment of Digestive Surgery, Beauvais General Hospital, Beauvais, France.
C MassonnaudDepartment of Biostatistics, Rouen University Hospital, 76000, Rouen, France.
J M RegimbeauDepartment of Digestive Surgery, Amiens University Hospital, Amiens, France.
J J TuechDepartment of Digestive Surgery, Rouen University Hospital, 76000, Rouen Cedex, France. Jean-jacques.tuech@chu-rouen.fr.ORCID http://orcid.org/0000-0001-9436-8938
Centre Hospitalier Universitaire de Rouen · FRCentre Hospitalier de Beauvais · FRCentre Hospitalier Universitaire Amiens-Picardie · FRCentre Hospitalier Universitaire de Limoges · FRDigestive Care (United States) · USHôpital de la Timone · FRInstitute for Biomedicine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgical management of Hinchey III and IV diverticulitis involves Hartmann's procedure (HP) or primary resection anastomosis (PRA) with or without fecal diversion. These procedures were evaluated in four randomized controlled trials. Early results from these trials demonstrated similar rates of complications but higher rates of colonic restoration after PRA than HP. Long-term follow-up has not been reported to date. The aim of this study was to analyze long-term outcomes and quality of life (QoL) in patients previously enrolled in a prospective randomized trial comparing HP and PRA for generalized peritonitis due to perforated diverticulitis (DIVERTI trial). STUDY

designFollow-up data were available for 78 of 102 patients. Demographic data, incisional hernia rate, need for additional surgery related to the primary procedure, and QoL were recorded.

resultsThe overall survival rate was 76% and did not differ between the two groups. Incisional hernia was reported in 21 (52%) patients in the HP arm and in 11 (29%) patients in the PRA arm (p = 0.035). The HP arm demonstrated significantly lower SF-36 physical and mental component scores. The mean general QoL (EQ-VAS) and mean EQ-5D index scores were better after PRA than after HP, but this difference was not statistically significant. The results of GIQLI, which measures intestine-specific QOL, did not differ between the two groups.

conclusionsThis follow-up study with a median follow-up time of > 9 years among living patients indicates that PRA for perforated diverticulitis is associated with fewer long-term complications and better QoL than HP. PRA significantly reduced the incisional hernia rate and the need for reoperation. Long-term survival was not jeopardized by the PRA approach. Future studies are needed to address the utility of protective stoma.

Indexed as

DiverticulitisDiverticulitis, ColonicIntestinal PerforationPeritonitisAnastomosis, SurgicalColostomyFollow-Up StudiesHumansProspective StudiesQuality of LifeTreatment OutcomeHartmann’s procedurePerforated diverticulitisPeritonitisPrimary anastomosisQuality of lifeRectosigmoid resection

Identifiers

PMID34086087
OpenAlexW3164474555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.