Evidence map›Paper›PMID 34086081›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2021

Gabra2 is a genetic modifier of Dravet syndrome in mice.

Nicole A Hawkins, Toshihiro Nomura, Samantha Duarte, Levi Barse, Robert W Williams, Gregg E Homanics, Megan K Mulligan, Anis Contractor, Jennifer A Kearney

Open access · hybridAbstract read
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Gene therapies alleviate absence epilepsy associated withbioRxiv : the preprint server for biology · 2025
    Article
  3. Review
  4. Article
  5. Dravet syndrome: novel insights intoFrontiers in neuroscience · 2025
    Review
  6. bioRxiv : the preprint server for biology · 2024
    Article
  7. Fine mapping and candidate gene analysis of Dravet syndrome modifier loci on mouse chromosomes 7 and 8.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
    Article
  8. Article
  9. Article
  10. γ-Aminobutyric acid transporter and GABABrain communications · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Kir5.1 channels: potential role in epilepsy and seizure disorders.American journal of physiology. Cell physiology · 2022
    Review
  15. Article
  16. Correction of the hypomorphicHGG advances · 2022
    Article
  17. Phenotypic and Genotypic Characteristics ofFrontiers in molecular neuroscience · 2022
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nicole A HawkinsDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Searle 8-450, Chicago, IL, 60611, USA.
Toshihiro NomuraDepartment of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Samantha DuarteDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Searle 8-450, Chicago, IL, 60611, USA.
Levi BarseDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Searle 8-450, Chicago, IL, 60611, USA.
Robert W WilliamsDepartment of Genetics, Genomics and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Gregg E HomanicsDepartment of Anesthesiology and Perioperative Medicine, Neurobiology, and Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Megan K MulliganDepartment of Genetics, Genomics and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Anis ContractorDepartment of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Jennifer A KearneyDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Searle 8-450, Chicago, IL, 60611, USA. jennifer.kearney@northwestern.edu.ORCID http://orcid.org/0000-0003-1726-4769
Northwestern University · USUniversity of Tennessee Health Science Center · USUniversity of Pittsburgh · US

Funding

Role of noncoding RNA in alcohol actionU01AA020889 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sean P Farris, Gregg E. Homanics · 2011 to 2026
$7.1M
Systems Genetics of Alcohol Response and Stress Effects in CNSU01AA013499 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2002 to 2016
$4.8M
The role of glutamate receptors in compulsive and perseverative behaviorR01MH099114 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CONTRACTOR, ANIS · 2012 to 2022
$4.5M
Genetic Modifiers of Childhood EpilepsyR01NS084959 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KEARNEY, JENNIFER A · 2014 to 2024
$4.2M
ETHANOL MECHANISMS IN GABAAR GENE TARGETED MICER01AA010422 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOMANICS, GREGG E. · 1995 to 2008
$3.1M
INIA-STRESS: Informatics and Analysis CoreU01AA016662 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILLIAMS, ROBERT W. · 2007 to 2016
$2.9M
LNCRNA REGULATION OF GENE EXPRESSION & BEHAVIORR01AA030257 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sean P Farris · 2022 to 2026
$2.8M
NIAAA NIH HHS R01 AA010422NIAAA NIH HHS R01 AA030257NIAAA NIH HHS U01 AA013499NIAAA NIH HHS U01 AA016662NIAAA NIH HHS U01 AA020889NIMH NIH HHS R01 MH099114NINDS NIH HHS R01 NS084959
6 · The paper itself

Abstract

Pathogenic variants in epilepsy genes result in a spectrum of clinical severity. One source of phenotypic heterogeneity is modifier genes that affect expressivity of a primary pathogenic variant. Mouse epilepsy models also display varying degrees of clinical severity on different genetic backgrounds. Mice with heterozygous deletion of Scn1a (Scn1a

Indexed as

AnimalsEpilepsies, MyoclonicMicePolymorphism, Single NucleotideReceptors, GABA-AGABRA2 protein, humanReceptors, GABA-A

Identifiers

PMID34086081
PMCPMC8458207
OpenAlexW3165059391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.