ArticleeLife2021
Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson's disease.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Using Magnetoencephalography to Advance the Science of Parkinson Disease: A Systematic Review.Brain and behavior · 2025Pooled it
- Dynamic neural states underpin motor symptom severity in Parkinson's disease: a longitudinal analysis of chronic cortico-subthalamic nucleus recordings.EBioMedicine · 2026Article
- Varying patterns of association between cortical large-scale networks and subthalamic nucleus activity in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Wavelet event-related EEG phase coherence as a discriminant biomarker of the cognitive status in Parkinson's and Lewy body disease.Frontiers in human neuroscience · 2026Article
- Beyond beta rhythms: subthalamic aperiodic broadband power scales with Parkinson's disease severity-a cross-sectional multicentre study.EBioMedicine · 2025Article
- Spontaneous network transitions predict somatosensory perception.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Electrophysiological signatures predict the therapeutic window of deep brain stimulation electrode contacts.NPJ digital medicine · 2025Article
- Subthalamic beta peak power ratio as an electrophysiological marker for deep brain stimulation contact selection in Parkinson's disease.Neurological research and practice · 2025Article
- Neural signatures of turn-induced freezing of gait in Parkinson's disease: insights from phase-specific cortico-subthalamic dynamics.NPJ Parkinson's disease · 2025Article
- Exploring the electrophysiology of Parkinson's disease with magnetoencephalography and deep brain recordings.Scientific data · 2024Article
- Dysfunction of motor cortices in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024Review
- Article
- Dissecting unsupervised learning through hidden Markov modeling in electrophysiological data.Journal of neurophysiology · 2023Article
- DBS-evoked cortical responses index optimal contact orientations and motor outcomes in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Alterations of PAC-based resting state networks in Parkinson's disease are partially alleviated by levodopa medication.Frontiers in systems neuroscience · 2023Article
- Dopaminergic Modulation of Local Non-oscillatory Activity and Global-Network Properties in Parkinson's Disease: An EEG Study.Frontiers in aging neuroscience · 2022Article
- Quantitative Electroencephalography as a Biomarker for Cognitive Dysfunction in Parkinson's Disease.Frontiers in aging neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathological oscillations including elevated beta activity in the subthalamic nucleus (STN) and between STN and cortical areas are a hallmark of neural activity in Parkinson's disease (PD). Oscillations also play an important role in normal physiological processes and serve distinct functional roles at different points in time. We characterised the effect of dopaminergic medication on oscillatory whole-brain networks in PD in a time-resolved manner by employing a hidden Markov model on combined STN local field potentials and magnetoencephalography (MEG) recordings from 17 PD patients. Dopaminergic medication led to coherence within the medial and orbitofrontal cortex in the delta/theta frequency range. This is in line with known side effects of dopamine treatment such as deteriorated executive functions in PD. In addition, dopamine caused the beta band activity to switch from an STN-mediated motor network to a frontoparietal-mediated one. In contrast, dopamine did not modify local STN-STN coherence in PD. STN-STN synchrony emerged both on and off medication. By providing electrophysiological evidence for the differential effects of dopaminergic medication on the discovered networks, our findings open further avenues for electrical and pharmacological interventions in PD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.