Evidence map›Paper›PMID 34085929›Full record

ArticleeLife2021

Short and long sleeping mutants reveal links between sleep and macroautophagy.

Joseph L Bedont, Hirofumi Toda, Mi Shi, Christine H Park, Christine Quake, Carly Stein, Anna Kolesnik, Amita Sehgal

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. A molecular integrator of sleep duration and interruption.bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Endocytosis at the mouse blood brain barrier is elevated during sleep.bioRxiv : the preprint server for biology · 2026
    Article
  5. Links Between Autophagy and Healthy Aging.Journal of molecular biology · 2026
    Review
  6. Review
  7. microPublication biology · 2026
    Article
  8. Article
  9. 25 years ofFly · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Cold-raising unmasks sleep disruption in amicroPublication biology · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. CorticalProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. TDP-43 impairs sleep inScience advances · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joseph L Bedont *Chronobiology and Sleep Institute, Perelman Medical School of University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-1614-4805
Hirofumi Toda *Chronobiology and Sleep Institute, Perelman Medical School of University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-6247-2826
Mi Shi *Chronobiology and Sleep Institute, Perelman Medical School of University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-3044-912X
Christine H ParkChronobiology and Sleep Institute, Perelman Medical School of University of Pennsylvania, Philadelphia, United States.
Christine QuakeChronobiology and Sleep Institute, Perelman Medical School of University of Pennsylvania, Philadelphia, United States.
Carly SteinChronobiology and Sleep Institute, Perelman Medical School of University of Pennsylvania, Philadelphia, United States.
Anna KolesnikChronobiology and Sleep Institute, Perelman Medical School of University of Pennsylvania, Philadelphia, United States.
Amita SehgalChronobiology and Sleep Institute, Perelman Medical School of University of Pennsylvania, Philadelphia, United States.ORCID 0000-0001-7354-9641
University of Pennsylvania · USHoward Hughes Medical Institute · US

Funding

Nitrogen metabolism in sleep homeostasis and pathologyK99NS118561 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BEDONT, JOSEPH L · 2020 to 2021
$186k
Characterizing metabolomic links between sleep deprivation and Alzheimers diseaseF32AG056081 · NIA · UNIVERSITY OF PENNSYLVANIA · PI BEDONT, JOSEPH L · 2017 to 2019
$137k
Howard Hughes Medical InstituteNIA NIH HHS F32 AG056081NINDS NIH HHS K99 NS118561
6 · The paper itself

Abstract

Sleep is a conserved and essential behavior, but its mechanistic and functional underpinnings remain poorly defined. Through unbiased genetic screening in

Indexed as

Gain of Function MutationNeuronsAnimalsAnimals, Genetically ModifiedAutophagosomesAutophagy-Related Protein-1 HomologDrosophila melanogasterDrosophila ProteinsGenotypeMacroautophagyMembrane ProteinsNerve Tissue ProteinsPhenotypeSleepTime FactorsWakefulnessAtg1 protein, DrosophilaAtg8a protein, Drosophilaaus protein, DrosophilaAutophagy-Related Protein-1 Homologbchs protein, DrosophilaDrosophila ProteinsMembrane ProteinsNerve Tissue Proteinsargusautophagyblue cheesecell biologyD. melanogasterDrosophilageneticsneurosciencesleep

Identifiers

PMID34085929
PMCPMC8177895
OpenAlexW3164139028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.