ArticleeLife2021
The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Identification and characterization of POSTNJournal of orthopaedic translation · 2026Article
- Genetically predicted cognitive performance and risk of meniscal derangement: A 2-sample Mendelian randomization study.Medicine · 2026Article
- Article
- Secretome from human placenta-derived mesenchymal stem cells repairs mechanically induced meniscus injury in mice by activating the proliferation and suppressing the apoptosis of endogenous meniscus progenitor cells.Stem cell research & therapy · 2025Article
- Hedgehog signaling directs cell differentiation and plays a critical role in tendon enthesis healing.NPJ Regenerative medicine · 2025Article
- The clinical potential of meniscal progenitor cells.The journal of cartilage & joint preservation · 2024Review
- β-catenin Orchestrates Gli1+ Cell Fate in Condylar Development and TMJOA.Journal of dental research · 2024Article
- Outcomes of Lateral Meniscal Oblique Radial Tear Repair Compared With Intact Meniscus After ACL Reconstruction: A Cohort Study.Orthopaedic journal of sports medicine · 2023Article
- Role of sonic hedgehog signaling pathway in the regulation of ion channels: focus on its association with cardio-cerebrovascular diseases.Journal of physiology and biochemistry · 2023Review
- Rapid specialization and stiffening of the primitive matrix in developing articular cartilage and meniscus.Acta biomaterialia · 2023Article
- Fracture healing-orthobiologics: from basic science to clinical application.OTA international : the open access journal of orthopaedic trauma · 2023Review
- From mesenchymal niches to engineeredMaterials today. Bio · 2022Article
- Multiplexed tape-stabilized cryohistology of mineralized large animal specimens.Journal of biological methods · 2022Article
- Hedgehog signaling underlying tendon and enthesis development and pathology.Matrix biology : journal of the International Society for Matrix Biology · 2022Review
- Sonic Hedgehog Induces Mesenchymal Stromal Cell Senescence-Associated Secretory Phenotype and Chondrocyte Apoptosis in Human Osteoarthritic Cartilage.Frontiers in cell and developmental biology · 2021Article
- Fibronectin Adherent Cell Populations Derived From Avascular and Vascular Regions of the Meniscus Have Enhanced Clonogenicity and Differentiation Potential Under Physioxia.Frontiers in bioengineering and biotechnology · 2021Article
- Recent Advances in Single-Cell View of Mesenchymal Stem Cell in Osteogenesis.Frontiers in cell and developmental biology · 2021Review
- Post-Traumatic Osteoarthritis Assessment in Emerging and Advanced Pre-Clinical Meniscus Repair Strategies: A Review.Frontiers in bioengineering and biotechnology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 8 institutions in 2 countries.
Yulong Wei *Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0003-3823-9984
Hao Sun *Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Tao Gui *Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Lutian YaoDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Leilei ZhongDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0003-1153-4115
Wei YuDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0001-6705-8264
Su-Jin HeoDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Lin HanSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, United States.
Nathaniel A DymentDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Xiaowei Sherry LiuDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Yejia ZhangDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Eiki KoyamaTranslational Research Program in Pediatric Orthopaedics, The Children's Hospital of Philadelphia, Philadelphia, United States.
Fanxin LongTranslational Research Program in Pediatric Orthopaedics, The Children's Hospital of Philadelphia, Philadelphia, United States.ORCID 0000-0001-9785-5379
Miltiadis H ZgonisDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Robert L MauckDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Jaimo AhnDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Ling QinDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-2582-0078
University of Pennsylvania · USPhiladelphia VA Medical Center · USChildren's Hospital of Philadelphia · USUnion Hospital · CNDrexel University · USFirst Affiliated Hospital of Jinan University · CNSun Yat-sen University · CNUniversity of Michigan · US
Funding
Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1MEGFR signaling in osteoarthritis and treatmentR01AG067698 · NIA · UNIVERSITY OF PENNSYLVANIA · PI QIN, LING · 2020 to 2024
$2.3MInhibition of TNF-alpha Signaling to Reduce Intervertebral Disc InflammationR21AR078386 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI ZHANG, YEJIA · 2021 to 2022
$383kADAM8 in Intervertebral Disc DegenerationR21AR071623 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI ZHANG, YEJIA · 2018 to 2019
$364kNIAMS NIH HHS P30 AR069619NIAMS NIH HHS R21 AR071623NIAMS NIH HHS R21 AR078386NIA NIH HHS R01 AG067698
Abstract
Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using a Gli1 reporter line, we found that Gli1
Indexed as
Mesenchymal Stem Cell TransplantationWound HealingAnimalsCell LineageCell ProliferationDisease Models, AnimalHedgehog ProteinsHumansMaleMenisci, TibialMesenchymal Stem CellsMiceMice, KnockoutOsteoarthritis, KneeSignal TransductionSwineGli1 protein, mouseHedgehog ProteinsZinc Finger Protein GLI1developmental biologyGli1lineage tracingmeniscus injurymesenchymal progenitormouseosteoarthritisregenerative medicinestem cells
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.