Evidence map›Paper›PMID 34085908›Full record

ArticleRNA biology2021

Yasutoshi Akiyama, Yoshihisa Tomioka, Takaaki Abe, Paul Anderson, Pavel Ivanov

Abstract read
In one paragraph

Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. RTCB Complex Regulates Stress-Induced tRNA Cleavage.International journal of molecular sciences · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yasutoshi AkiyamaLaboratory of Oncology, Pharmacy Practice and Sciences, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan.
Yoshihisa TomiokaLaboratory of Oncology, Pharmacy Practice and Sciences, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan.
Takaaki AbeDepartment of Medical Science, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan.
Paul AndersonDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA.
Pavel IvanovDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-7986-7760

Funding

Cellular Stress Response MechanismsR35GM126901 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ANDERSON, PAUL J. · 2018 to 2022
$2.9M
Biology of RNA G-quadruplexesR01GM126150 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI IVANOV, PAVEL · 2019 to 2023
$1.9M
tRNA-derived stress-induced RNAs and translational controlR01GM146997 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI IVANOV, PAVEL · 2022 to 2025
$1.6M
NIGMS NIH HHS R01 GM126150NIGMS NIH HHS R01 GM146997NIGMS NIH HHS R35 GM126901
6 · The paper itself

Abstract

Under adverse conditions, tRNAs are processed into fragments called tRNA-derived stress-induced RNAs (tiRNAs) by stress-responsive ribonucleases (RNases) such as angiogenin (ANG). Recent studies have reported several biological functions of synthetic tiRNAs lacking post-transcriptional modifications found on endogenous tiRNAs. Here we describe a simple and reproducible method to efficiently isolate ANG-cleaved tiRNAs from endogenous tRNAs. Using this

Indexed as

RNA Processing, Post-TranscriptionalAngiogenesis Inducing AgentsHumansRibonuclease, PancreaticRNA, TransferTumor Cells, CulturedAngiogenesis Inducing AgentsangiogeninRibonuclease, PancreaticRNA, TransferstresstiRNAstRNAtRNA-derived fragments

Identifiers

PMID34085908
PMCPMC8632075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.