Evidence map›Paper›PMID 34085843›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Improving characterization of hypertrophy-induced murine cardiac dysfunction using four-dimensional ultrasound-derived strain mapping.

Frederick W Damen, John P Salvas, Andrea S Pereyra, Jessica M Ellis, Craig J Goergen

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

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  11. Application of 4-D ultrasound-derived regional strain and proteomics analysis inAmerican journal of physiology. Heart and circulatory physiology · 2023
    Article
  12. Localized strain characterization of cardiomyopathy in Duchenne muscular dystrophy using novel 4D kinematic analysis of cine cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  13. Article
  14. Quantification of murine myocardial infarct size using 2-D and 4-D high-frequency ultrasound.American journal of physiology. Heart and circulatory physiology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Frederick W DamenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana.ORCID 0000-0001-9213-5508
John P SalvasWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana.
Andrea S PereyraDepartment of Physiology, East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.ORCID 0000-0001-7596-2421
Jessica M EllisDepartment of Physiology, East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, North Carolina.
Craig J GoergenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana.ORCID 0000-0001-8883-7953
Purdue University West Lafayette · USEast Carolina University · US

Funding

Determining the Biological Effects of Mitochondrial Acyl ToxicityR01DK125812 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ELLIS, JESSICA M · 2020 to 2025
$2.3M
Interdisciplinary Bioengineering Training in Diabetes ResearchT32DK101001 · NIDDK · PURDUE UNIVERSITY · PI EVANS-MOLINA, CARMELLA, VOYTIK-HARBIN, SHERRY L · 2013 to 2022
$1.6M
Spatial Analysis of Cardiac Disease using Murine Four-Dimensional UltrasoundF30HL145980 · NHLBI · PURDUE UNIVERSITY · PI DAMEN, FREDERICK W · 2019 to 2021
$141k
NHLBI NIH HHS F30 HL145980NIDDK NIH HHS R01 DK125812NIDDK NIH HHS T32 DK101001
6 · The paper itself

Abstract

Mouse models of cardiac disease have become essential tools in the study of pathological mechanisms, but the small size of rodents makes it challenging to quantify heart function with noninvasive imaging. Building off recent developments in high-frequency four-dimensional ultrasound (4DUS) imaging, we have applied this technology to study cardiac dysfunction progression in a murine model of metabolic cardiomyopathy. Cardiac knockout of carnitine palmitoyltransferase 2 (

Indexed as

AnimalsCardiomegalyCarnitine O-PalmitoyltransferaseEchocardiography, Four-DimensionalFemaleHeartMiceMice, KnockoutVentricular Function, LeftCarnitine O-Palmitoyltransferasecontractilityfour-dimensional ultrasoundhypertrophyleft ventriclestrain mapping

Identifiers

PMID34085843
PMCPMC8321816
OpenAlexW3165219945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.