ArticleInvestigative and clinical urology2021
The clinical impact of strict criteria for active surveillance of prostate cancer in Korean population: Results from a prospective cohort.
Article in Investigative and clinical urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Does protocol heterogeneity in active surveillance influence clinical outcomes? Insights from a multicenter prostate cancer cohort.Investigative and clinical urology · 2026Article
- Standardizing Prostate MRI Reporting in Active Surveillance for Prostate Cancer: The PRECISE Framework.Journal of the Korean Society of Radiology · 2025Review
- Is There a Difference in the Incidence of Depression between Radiation and Surgical Treatments in Patients with Prostate Cancer?The world journal of men's health · 2024Article
- Article
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Authors and funding
8 authors at 4 institutions in 1 country.
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Abstract
purposeTo evaluate the clinical impact of strict selection criteria for active surveillance (AS) of prostate cancer in a Korean population. MATERIALS AND
methodsA single-center, prospectively collected AS cohort from December 2016 to February 2019 was used. Following pre-determined criteria, patients were categorized into "strict AS" and "non-strict AS" groups. Clinicopathological progression-free survival (PFS) and treatment-free survival (TFS) of the two groups were compared using the Kaplan-Meier curve and log-rank test. Age-adjusted hazard ratios for clinicopathological progression was calculated using Cox proportional regression analysis.
resultsOf 54 eligible patients, 25 and 29 were assigned to "strict AS" and "non-strict AS," respectively. Clinicopathological progression and definitive treatment rates were 24.0% (6 of 25 patients) vs. 51.7% (15 of 29 patients) and 32.0% (8 of 25 patients) vs. 62.1% (18 of 29 patients) in "strict AS" and "non-strict AS" groups. Progress to high-risk cancer (pathologic T3 or surgical Gleason Grade 2 over) in radical prostatectomy was higher in "non-strict AS" than "strict AS". PFS (mean 34.6±2.9 mo vs. 22.6±2.7 mo; p=0.025) and TFS (mean 31.8±3.2 mo vs. 19.6±2.4 mo; p=0.018) favor the "strict AS" group than "non-strict AS" group. Age-adjusted hazard ratio for clinicopathological progression of strict criteria was 0.36 (95% confidence interval, 0.14-0.94; p=0.04).
conclusionsPFS and TFS were better in the "strict AS" group than in the "non-strict AS" group. This finding should be informed to relevant patients during decision making and considered in Korean guidelines.
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