Evidence map›Paper›PMID 34085786›Full record

ArticleInvestigative and clinical urology2021

Expression of phosphorylated p21-activated kinase 4 is associated with aggressive histologic characteristics and poor prognosis in patients with surgically treated renal cell carcinoma.

Ho Won Kang, Xuan Mei Piao, Hee Youn Lee, Kyeong Kim, Sung Pil Seo, Yun Sok Ha, Yeong Uk Kim, Won Tae Kim, Yong June Kim, Sang Cheol Lee and 4 more

Abstract read
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In one paragraph

Article in Investigative and clinical urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ho Won Kang *Department of Urology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea.ORCID 0000-0002-8164-4427
Xuan Mei Piao *Department of Urology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea.ORCID 0000-0001-6847-7743
Hee Youn LeeDepartment of Urology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea.ORCID 0000-0001-8065-2807
Kyeong KimDepartment of Urology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea.ORCID 0000-0003-3353-4431
Sung Pil SeoDepartment of Urology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea.ORCID 0000-0003-3721-6000
Yun Sok HaDepartment of Urology, School of Medicine, Kyungpook National University, Daegu, Korea.ORCID 0000-0003-3732-9814
Yeong Uk KimDepartment of Urology, School of Medicine, Yeungnam University, Daegu, Korea.ORCID 0000-0002-8783-9567
Won Tae KimDepartment of Urology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea.ORCID 0000-0002-7482-4550
Yong June KimDepartment of Urology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea.ORCID 0000-0001-7638-7174
Sang Cheol LeeDepartment of Urology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea.ORCID 0000-0002-4163-2210
Wun Jae KimDepartment of Urology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea.ORCID 0000-0002-8060-8926
Eun Young ShinDepartment of Biochemistry and Medical Research Center, College of Medicine, Chungbuk National University, Cheongju, Korea.ORCID 0000-0001-6128-4180
Eung Gook KimDepartment of Biochemistry and Medical Research Center, College of Medicine, Chungbuk National University, Cheongju, Korea. egkim@chungbuk.ac.kr.ORCID 0000-0001-8232-5666
Seok Joong YunDepartment of Urology, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea. sjyun@chungbuk.ac.kr.ORCID 0000-0001-7737-4746

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeP21-activated kinase 4 (PAK4), a serine/threonine kinase that regulates a number of fundamental cellular processes, has been suggested as a prognostic factor for various human tumors. The aim of the present study was to evaluate the clinical implications of phospho-Ser474 PAK4 (pPAK4 MATERIALS AND

methodsSamples from 131 patients with surgically treated RCC were immunostained to detect PAK4 and pPAK4

resultsPAK4 and pPAK4

conclusionspPAK4

Indexed as

AgedCarcinoma, Renal CellCell NucleusCytoplasmFemaleHumansKaplan-Meier EstimateKidney NeoplasmsMaleMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm Stagingp21-Activated KinasesPhosphorylationPrognosisp21-Activated KinasesPAK4 protein, humanP21-activated kinase 4RecurrenceRenal cell carcinomaSurvival

Identifiers

PMID34085786
PMCPMC8246022

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.