Evidence map›Paper›PMID 34085779›Full record

ArticleCPT: pharmacometrics & systems pharmacology2021

Pharmacometric analysis linking immunoglobulin exposure to clinical efficacy outcomes in chronic inflammatory demyelinating polyneuropathy.

Michael A Tortorici, Theresa Yuraszeck, David Cornblath, Vera Bril, Hans-Peter Hartung, Gen Sobue, Richard A Lewis, Ingemar S J Merkies, John-Philip Lawo, Michaela Praus and 7 more

Open access · goldAbstract read
In one paragraph

Article in CPT: pharmacometrics & systems pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 10 countries.

Michael A TortoriciCSL Behring, King of Prussia, Pennsylvania, USA.
Theresa YuraszeckCSL Behring, King of Prussia, Pennsylvania, USA.
David CornblathDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Vera BrilEllen and Martin Prosserman Centre for Neuromuscular Diseases, Division of Neurology, Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.
Hans-Peter HartungDepartment of Neurology, UKD and Center for Neurology and Neuropsychiatry, LVR Klinikum, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Gen SobueDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Richard A LewisDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Ingemar S J MerkiesDepartment of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.
John-Philip LawoCSL Behring, Marburg, Germany.
Michaela PrausCSL Behring, Marburg, Germany.
Billie L DurnCSL Behring, King of Prussia, Pennsylvania, USA.
Orell MielkeCSL Behring, Marburg, Germany.
Xuewen MaCSL Behring, King of Prussia, Pennsylvania, USA.
Petra JauslinCertara, Princeton, New Jersey, USA.
Marc PfisterUniversity of Basel, Basel, Switzerland.
Ivo N van SchaikDepartment of Neurology, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, The Netherlands.
PATH study group
CSL (United States) · USBehringwerke (Germany) · DECedars-Sinai Medical Center · USHeinrich Heine University Düsseldorf · DEIntegra LifeSciences (United States) · USJohns Hopkins Medicine · USMaastricht University · NLNagoya University · JPSpaarne Ziekenhuis · NLUniversity Health Network · CAUniversity of Basel · CH

Funding

CSL Behring
6 · The paper itself

Abstract

The two main objectives of this analysis were to (i) characterize the relationship between immunoglobulin (Ig) exposure and chronic inflammatory demyelinating polyneuropathy (CIDP) disease severity using data from 171 patients with CIDP who received either subcutaneous Ig (IgPro20; Hizentra

Indexed as

Models, BiologicalAdultAgedAged, 80 and overDrug Administration ScheduleFemaleHumansImmunoglobulin GImmunologic FactorsInjections, SubcutaneousMaleMiddle AgedPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingRandomized Controlled Trials as TopicTreatment OutcomeYoung AdultHizentraImmunoglobulin GImmunologic Factors

Identifiers

PMID34085779
PMCPMC8376132
OpenAlexW3164065928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.