Evidence map›Paper›PMID 34085769›Full record

Trial reportCPT: pharmacometrics & systems pharmacology2021

A population pharmacokinetic-pharmacodynamic model of YH12852, a highly selective 5-hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation.

Siun Kim, Hyun A Lee, Seong Bok Jang, Howard Lee

Open access · goldAbstract readClinical Trial, Phase IClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in CPT: pharmacometrics & systems pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Siun KimDepartment of Applied Biomedical Engineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.ORCID 0000-0003-1090-3978
Hyun A LeeDepartment of Applied Biomedical Engineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
Seong Bok JangClinical Development Department, Research & Development Division, Yuhan Corporation, Seoul, Korea.
Howard LeeDepartment of Applied Biomedical Engineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.ORCID 0000-0001-6713-5418
Seoul National University of Science and Technology · KRKorea Development Institute · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

YH12852, a novel, highly selective 5-hydroxytryptamine 4 (5-HT

Indexed as

Models, BiologicalAdultCase-Control StudiesComputer SimulationConstipationDose-Response Relationship, DrugDouble-Blind MethodFemaleGastric EmptyingHumansMaleMiddle AgedPyrimidinesSerotonin 5-HT4 Receptor AgonistsSeverity of Illness IndexYoung AdultPyrimidinesSerotonin 5-HT4 Receptor AgonistsYH12852

Identifiers

PMID34085769
PMCPMC8376136
OpenAlexW3164425223

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.