Evidence map›Paper›PMID 34085724›Full record

ArticleClinical cardiology2021

Importance of epicardial adipose tissue localization using cardiac magnetic resonance imaging in patients with heart failure with mid-range and preserved ejection fraction.

Gijs van Woerden, Dirk J van Veldhuisen, Thomas M Gorter, Vanessa P M van Empel, Martin E W Hemels, Eric J Hazebroek, Sophie L van Veldhuisen, Tineke P Willems, Michiel Rienstra, Berend Daan Westenbrink

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Gijs van WoerdenDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.ORCID https://orcid.org/0000-0001-7907-2944
Dirk J van VeldhuisenDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Thomas M GorterDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Vanessa P M van EmpelDepartment of Cardiology, University of Maastricht, Medical University Centre Maastricht, Maastricht, Netherlands.
Martin E W HemelsDepartment of Cardiology, Rijnstate Hospital, Arnhem, Netherlands.
Eric J HazebroekDepartment of Surgery, Rijnstate Hospital, Arnhem, Netherlands.
Sophie L van VeldhuisenDepartment of Surgery, Rijnstate Hospital, Arnhem, Netherlands.
Tineke P WillemsDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Michiel RienstraDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Berend Daan WestenbrinkDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
University Medical Center Groningen · NLRijnstate Hospital · NLMaastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpicardial adipose tissue (EAT) has been implicated in the pathophysiology of heart failure (HF) with left ventricular ejection fraction (LVEF) >40%, but whether this is due to a regional or global effect of EAT remains unclear. HYPOTHESIS: Regional EAT is associated with alterations in local cardiac structure and function.

methodsPatients with HF and LVEF >40% were studied. Cardiac Magnetic Resonance imaging was used to localize EAT surrounding the right ventricle (RV) and LV separately, using anterior- and posterior interventricular grooves as boundaries. Atrial- and ventricular EAT were differentiated using the mitral-valve position. All EAT depots were related to the adjacent myocardial structure.

results102 consecutive HF patients were enrolled. The majority of EAT was present around the RV (42% of total EAT, p < .001). RV-EAT showed a strong association with increased RV mass (β = 0.60, p < .001) and remained associated with RV mass after adjusting for total EAT, sex, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), renal function and blood glucose. LV-EAT showed a similar association with LV mass in univariable analysis, albeit less pronounced (β = 0.24, p = .02). Atrial EAT was increased in patients with atrial fibrillation compared to those without atrial fibrillation (30 vs. 26 ml/m

conclusionsRegional EAT is strongly associated with local cardiac structure and function in HF patients with LVEF >40%. These data support the hypothesis that regional EAT is involved in the pathophysiology of HF with LVEF >40%.

Indexed as

Heart FailureVentricular Function, LeftAdipose TissueHumansMagnetic Resonance ImagingPrognosisStroke Volumecardiac magnetic resonance imagingEATHFmrEFHFpEF

Identifiers

PMID34085724
PMCPMC8259147
OpenAlexW3164307539

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.