Evidence map›Paper›PMID 34085589›Full record

ArticleAutophagy2021

Mitochondrial autophagy and cell survival is regulated by the circadian

Inna Rabinovich-Nikitin, Mina Rasouli, Cristine J Reitz, Illana Posen, Victoria Margulets, Rimpy Dhingra, Tarak N Khatua, James A Thliveris, Tami A Martino, Lorrie A Kirshenbaum

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 142 citations in OpenAlex.

  1. Article
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  6. The ClockJournal of orthopaedic surgery and research · 2026
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  12. The ATG14: multi-layer autophagy control and an emerging therapeutic target in cancer.Apoptosis : an international journal on programmed cell death · 2026
    Review
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Inna Rabinovich-NikitinDepartment of Physiology and Pathophysiology, The Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
Mina RasouliCentre for Cardiovascular Investigations, Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
Cristine J ReitzCentre for Cardiovascular Investigations, Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
Illana PosenDepartment of Physiology and Pathophysiology, The Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
Victoria MarguletsDepartment of Physiology and Pathophysiology, The Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
Rimpy DhingraDepartment of Physiology and Pathophysiology, The Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
Tarak N KhatuaCentre for Cardiovascular Investigations, Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
James A ThliverisDepartment of Human Anatomy and Cell Science, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Tami A MartinoCentre for Cardiovascular Investigations, Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.
Lorrie A KirshenbaumDepartment of Physiology and Pathophysiology, The Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada.
St. Boniface Hospital · CAUniversity of Guelph · CAUniversity of Manitoba · CA

Funding

CIHR
6 · The paper itself

Abstract

Cardiac function is highly reliant on mitochondrial oxidative metabolism and quality control. The circadian

Indexed as

Cell SurvivalMitophagyAnimalsCLOCK ProteinsIschemiaMaleMembrane Potential, MitochondrialMiceMice, Inbred C57BLMitochondria, HeartMyocytes, CardiacClock protein, mouseCLOCK ProteinsAutophagyclockmetabolismmitochondrionmyocardial infarction

Identifiers

PMID34085589
PMCPMC8632283
OpenAlexW3165762063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.