Evidence map›Paper›PMID 34085373›Full record

ArticleGenes, brain, and behavior2022

Mice with an autism-associated R451C mutation in neuroligin-3 show a cautious but accurate response style in touchscreen attention tasks.

Emma L Burrows, Carlos May, Thomas Hill, Leonid Churliov, Katherine A Johnson, Anthony J Hannan

Abstract read
In one paragraph

Article in Genes, brain, and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emma L BurrowsFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-6675-4679
Carlos MayFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Thomas HillFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Leonid ChurliovFlorey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia.
Katherine A JohnsonSchool of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia.
Anthony J HannanFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the earliest identifiable features of autism spectrum disorder (ASD) is altered attention. Mice expressing the ASD-associated R451C mutation in synaptic adhesion protein neuroligin-3 (NL3) exhibit impaired reciprocal social interactions and repetitive and restrictive behaviours. The role of this mutation in attentional abnormalities has not been established. We assessed attention in male NL3

Indexed as

AttentionPhenotypeRewardAnimalsAutistic DisorderCell Adhesion Molecules, NeuronalCognitionFemaleMaleMembrane ProteinsMiceMutation, MissenseNerve Tissue ProteinsCell Adhesion Molecules, NeuronalMembrane ProteinsNerve Tissue Proteinsneuroligin 35-choice serial reaction taskattentionautism spectrum disordercontinuous performance taskgene-edited mouse modelinformation processingneuroligin-3R451C mutationresponse timestouchscreen tests

Identifiers

PMID34085373
PMCPMC9744539

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.