Evidence map›Paper›PMID 34085343›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Trypanosoma cruzi Letm1 is involved in mitochondrial Ca

Guilherme Rodrigo Rm Dos Santos, Ana Catarina Rezende Leite, Noelia Lander, Miguel Angel Chiurillo, Aníbal Eugênio Vercesi, Roberto Docampo

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Cloning-Free Genome Editing by CRISPR/T7RNAP/Cas9 in Trypanosoma cruzi.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  2. Imaging CaMethods in molecular biology (Clifton, N.J.) · 2026
    Article
  3. Article
  4. Mitochondrial CaAntioxidants & redox signaling · 2022
    Review
  5. The Kinetoplastid-Specific Protein TcCAL1 Plays Different Roles DuringFrontiers in cellular and infection microbiology · 2022
    Article
  6. The long and winding road of reverse genetics inMicrobial cell (Graz, Austria) · 2021
    Article
  7. Review
  8. Gene editing of putative cAMP and CaThe Journal of eukaryotic microbiology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Guilherme Rodrigo Rm Dos SantosDepartamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil.
Ana Catarina Rezende LeiteLaboratório de Bioenergética, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió, Brazil.
Noelia LanderCenter of Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA.
Miguel Angel ChiurilloCenter of Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA.
Aníbal Eugênio VercesiDepartamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil.
Roberto DocampoDepartamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil.ORCID 0000-0003-4229-8784
University of Georgia · USUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Alagoas · BR

Funding

Calcium signaling in Trypanosoma bruceiR01AI108222 · NIAID · UNIVERSITY OF GEORGIA · PI DOCAMPO, ROBERTO · 2014 to 2017
$1.5M
Large-scale CRISPR screening of essential calcium-related genes in the human parasite Trypanosoma cruziK99AI137322 · NIAID · UNIVERSITY OF GEORGIA · PI LANDER, NOELIA · 2019 to 2020
$209k
NIAID NIH HHS K99 AI137322NIAID NIH HHS R01 AI108222
6 · The paper itself

Abstract

Leucine zipper-EF-hand containing transmembrane protein 1 (Letm1) is a mitochondrial inner membrane protein involved in Ca

Indexed as

Cell DifferentiationAnimalsBiological TransportCalciumCalcium-Binding ProteinsChagas DiseaseChlorocebus aethiopsEnergy MetabolismMembrane Potential, MitochondrialMitochondriaProtozoan ProteinsTrypanosoma cruziVero CellsCalciumCalcium-Binding ProteinsProtozoan Proteinscalcium signalingcell bioenergeticsLetm1mitochondriaTrypanosoma cruzi

Identifiers

PMID34085343
PMCPMC10437107
OpenAlexW3165370574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.