Evidence map›Paper›PMID 34085181›Full record

ReviewPharmacological reports : PR2021

Use of glucocorticoids and azithromycin in the therapy of COVID-19.

Miguel de Lemos Neto, Rafael Costa Vieira Alexandre, Rafaela Oliveira Gallart Morra, Juliana Aparecida Souza da Paz, Shana Priscila Coutinho Barroso, Angela Castro Resende, Daniel J M de Medeiros-Lima, Pedro Celso Braga Alexandre

Open access · bronzeAbstract readReview
In one paragraph

Review in Pharmacological reports : PR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Efficacy of Bed Exercise Following Primary Total Hip Replacement in Young Active Patients.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  3. Biomimetic erythrocyte-based drug delivery systems for organ-targeted therapy.Frontiers in bioengineering and biotechnology · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Miguel de Lemos NetoFaculty of Medicine of Campos dos Goytacazes, Av. Alberto Torres, 217, Campos dos Goytacazes, Brazil.
Rafael Costa Vieira AlexandreDepartment of Pharmacology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
Rafaela Oliveira Gallart MorraDepartment of Pharmacology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
Juliana Aparecida Souza da PazMolecular Biology Laboratory, Biomedical Research Institute, Marcílio Dias Navy Hospital, Rio de Janeiro, Brazil.
Shana Priscila Coutinho BarrosoMolecular Biology Laboratory, Biomedical Research Institute, Marcílio Dias Navy Hospital, Rio de Janeiro, Brazil.
Angela Castro ResendeDepartment of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Daniel J M de Medeiros-LimaFaculty of Medicine of Campos dos Goytacazes, Av. Alberto Torres, 217, Campos dos Goytacazes, Brazil. daniel.jose@fmc.br.ORCID http://orcid.org/0000-0003-4930-0533
Pedro Celso Braga AlexandreDepartment of Pharmacology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
Universidade Federal do Estado do Rio de Janeiro · BRPrefeitura Municipal de Campos dos Goytacazes · BRUniversidade do Estado do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In December 2019, a new variant coronavirus, SARS-CoV-2, emerged in China, which was initially described as a pneumonia of an unknown agent. The new coronavirus spreads mainly by person-to-person transmission through close contact. The pathophysiology of COVID-19 is related to a complex immune system response that varies between people and, in severe cases of the disease, is characterized by excessive responses called "cytokine storms," which are associated with complications that can lead to a state of hypercoagulation and death. Glucocorticoids and azithromycin are drugs that may be effective in the treatment. This review aims to highlight the clinical findings that demonstrate the effectiveness of glucocorticoid and azithromycin therapy in the treatment of COVID-19. To date, many drugs have been studied for use in combination therapy, and the rapid expansion of knowledge about the virology of SARS-CoV-2 generates a more accurate direction in therapy.

Indexed as

COVID-19 Drug TreatmentAzithromycinCOVID-19Drug CombinationsGlucocorticoidsHumansSARS-CoV-2AzithromycinDrug CombinationsGlucocorticoidsAntibioticsCOVID-19GlucocorticoidsSARS-CoV-2

Identifiers

PMID34085181
PMCPMC8175191
OpenAlexW3165170521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.