ArticleBehavior genetics2021
Genetic Moderation of the Association Between Early Family Instability and Trajectories of Aggressive Behaviors from Middle Childhood to Adolescence.
Article in Behavior genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- Developmental profiles of child behavior problems from 18 months to 8 years: The protective effects of structured parenting vary by genetic risk.Development and psychopathology · 2022Article
- An Introduction to the Special Issue: Developmental Behavior Genetics and Externalizing Psychopathology.Behavior genetics · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The present study tested models of polygenic by environment interaction between early childhood family instability and polygenic risk for aggression predicting developmental trajectories of aggression from middle childhood to adolescence. With a longitudinal sample of 515 racially and ethnically diverse children from low-income families, primary caregivers reported on multiple components of family instability annually from child ages 2-5 years. A conservative polygenic risk score (p = 0.05) was generated based on a prior meta-genome wide association study. Trajectories of aggression were identified using a curve of factors model based on a composite of primary caregiver, alternate caregiver, and teacher reports at five ages from 7.5 to 14 years. The family instability by polygenic interaction predicted growth in children's aggression such that children with lower levels of family instability and lower polygenic risk exhibited a steeper decline in aggression from 7.5 to 14. Findings support the need to model gene-environment interplay to elucidate the role of genetics in the development of aggressive behaviors.
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Registered trials
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