ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022
Diagnostic performance of White Blood Cell SPECT imaging against intra-operative findings in patients with a suspicion of prosthetic valve endocarditis.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- Synthesis and Evaluation ofPharmaceutics · 2024Article
- Novel Diagnostic Methods for Infective Endocarditis.International journal of molecular sciences · 2024Review
- Multimodality Imaging Diagnosis in Infective Endocarditis.Life (Basel, Switzerland) · 2023Review
- Prognosis and follow-up of patients with prosthetic valve endocarditis treated conservatively in relation to WBC-SPECT imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Advances in Molecular Imaging in Infective Endocarditis.Vaccines · 2023Review
- Negative influence of antimicrobial therapy on radiolabeled white blood cells scintigraphy performance in infective endocarditis: myth or fact?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Alternative Nuclear Imaging Tools for Infection Imaging.Current cardiology reports · 2022Review
- Infective Endocarditis White Blood Cell Imaging: Is There an Added Value to the First-Line Imaging?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Nuclear Imaging in Infective Endocarditis.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Relevance of cardiac imaging in the evolving landscape of infective endocarditis management.Therapeutic advances in cardiovascular diseaseReview
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe objective of this study was to evaluate the diagnostic performance of white blood cells (WBC)-SPECT imaging in patients with suspicion of prosthetic valve endocarditis (PVE) against intra-operative findings.
methods36 consecutive patients who underwent cardiac surgery 30 days after WBC-SPECT imaging were identified retrospectively. Clinical, imaging, and biological results were collected from reports. WBC-SPECT results were classified as positive or negative and, if positive, the intensity of signal graded as intense or mild. Lesions observed during cardiac surgery were collected from surgeons' reports.
resultsThe 20 patients with positive WBC-SPECT study had confirmed PVE intra-operatively. Patients with intense signal on WBC-SPECT had high prevalence of abscesses (83%) compared to patients with only mild signal (12%). The three patients with negative WBC-SPECT but confirmed PVE had longer duration of antibiotic treatment before imaging and had no perivalvular abscess. Sensitivity, specificity, positive predictive and negative values, and accuracy of WBC-SPECT were measured at 87%, 100%, 100%, 81%, and 92%, respectively. Addition of WBC-SPECT results to the modified Duke score helped re-classify correctly 25% of patients from possible to definite PVE.
conclusionIn patients with suspicion of PVE, WBC-SPECT imaging provides excellent diagnostic performance against intra-operative findings.
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