Evidence map›Paper›PMID 34085060›Full record

ArticleNeurology (E-Cronicon)2021

Psychoactive Drugs Like Cannabis -Induce Hypodopaminergic Anhedonia and Neuropsychological Dysfunction in Humans: Putative Induction of Dopamine Homeostasis via Coupling of Genetic Addiction Risk Severity (GARS) testing and Precision Pro-dopamine Regulation (KB220).

Kenneth Blum, Joseph Morgan, Jean Lud Cadet, David Baron, Paul R Carney, Jag Khalsa, Rajendra D Badgaiyan, Mark S Gold

Open access · greenAbstract read
In one paragraph

Article in Neurology (E-Cronicon), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Are We Getting High Cause the Thrill is Gone?Journal of addiction psychiatry · 2023
    Article
  7. Review
  8. Article
  9. Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 2 countries.

Kenneth BlumWestern University Health Sciences, Pomona, CA, USA.
Joseph MorganSubstance Use Disorders Institute University of Sciences, Philadelphia, PA, USA.
Jean Lud CadetMolecular Neuropsychiatry Research Branch, DHHS/NIH/NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
David BaronWestern University Health Sciences, Pomona, CA, USA.
Paul R CarneyNeuroscience Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jag KhalsaDepartment of Microbiology, immunology and Tropical Medicine, George Washington University, School of Medicine and Health Sciences, Washington, DC, USA.
Rajendra D BadgaiyanDepartment of Psychiatry, Long School of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.
Mark S GoldDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
George Washington University · USPhiladelphia University · USThe University of Texas Health Science Center at San Antonio · USUnited States Department of Health and Human Services · USUniversity of North Carolina at Chapel Hill · USWashington University in St. Louis · USWestern University of Health Sciences · USWright State University · US

Funding

Neurotoxicity in the adult rat following chronic exposure to methamphetamineZIADA000552 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI CADET, JEAN LUD · 2009 to 2025
$34.3M
Dopamine Neurotransmission in Tourette SyndromeR01NS073884 · NINDS · UNIVERSITY OF MINNESOTA · PI BADGAIYAN, RAJENDRA D · 2012 to 2016
$2.2M
A Systematic Medical Approach to Reward Transformation (SMART) for Brain Health in Opioid Use DisorderR41MD012318 · NIMHD · VERSA INTEGRATED SOLUTIONS, INC. · PI BLUM, KENNETH, GONDRE-LEWIS, MARJORIE C · 2017 to 2017
$221k
NIMHD NIH HHS R41 MD012318NINDS NIH HHS R01 NS073884
6 · The paper itself

Abstract

Many US states now embrace the medical and recreational use of Cannabis. Changes in the laws have heightened interest and encouraged research into both cannabinoid products and the potential harms of Cannabis use, addiction and intoxication. The major active ingredient of

Indexed as

Cannabis sativaCannabis Use Disorder (CUD)Type-1 Cannabinoid (CB1) ReceptorΔ9-tetrahydrocannabinol (THC)

Identifiers

PMID34085060
PMCPMC8171216
OpenAlexW3152587372

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.