Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents.
Paul J Koovits, Marco A Dessoy, An Matheeussen, Louis Maes, Guy Caljon, Leonardo L G Ferreira, Rafael C Chelucci, Simone Michelan-Duarte, Adriano D Andricopulo, Simon Campbell and 3 more
Article in RSC medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors.
Paul J KoovitsInstitute of Chemistry, University of Campinas (UNICAMP) Rua Josué de Castro, S/N, Cidade Universitária Campinas SP 13083-861 Brazil ldias@iqm.unicamp.br +55 19 3521 3097.
Marco A DessoyInstitute of Chemistry, University of Campinas (UNICAMP) Rua Josué de Castro, S/N, Cidade Universitária Campinas SP 13083-861 Brazil ldias@iqm.unicamp.br +55 19 3521 3097.
An MatheeussenLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp Universiteitsplein 1 2610 Wilrijk Belgium.
Louis MaesLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp Universiteitsplein 1 2610 Wilrijk Belgium.
Guy CaljonLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp Universiteitsplein 1 2610 Wilrijk Belgium.
Leonardo L G FerreiraLaboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos, University of Sao Paulo Av. Joao Dagnone 1100 13563-120 Sao Carlos-SP Brazil.ORCID https://orcid.org/0000-0002-6947-0639
Rafael C ChelucciLaboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos, University of Sao Paulo Av. Joao Dagnone 1100 13563-120 Sao Carlos-SP Brazil.
Simone Michelan-DuarteLaboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos, University of Sao Paulo Av. Joao Dagnone 1100 13563-120 Sao Carlos-SP Brazil.
Adriano D AndricopuloLaboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos, University of Sao Paulo Av. Joao Dagnone 1100 13563-120 Sao Carlos-SP Brazil.ORCID https://orcid.org/0000-0002-0457-818X
Simon CampbellDrugs for Neglected Diseases initiative (DNDi) 15 Chemin Louis-Dunant 1202 Geneva Switzerland.
Luiz C DiasInstitute of Chemistry, University of Campinas (UNICAMP) Rua Josué de Castro, S/N, Cidade Universitária Campinas SP 13083-861 Brazil ldias@iqm.unicamp.br +55 19 3521 3097.ORCID https://orcid.org/0000-0003-0628-9928
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
A series of benzene sulphonamides with good potency and selectivity against
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents. · full record | OpenQuestion