Evidence map›Paper›PMID 34084656›Full record

ArticleAmerican journal of cardiovascular disease2021

Pre-existing cardiovascular disease, acute kidney injury, and cardiovascular outcomes in hospitalized blacks with COVID-19 infection.

Obiora Egbuche, Opeyemi Jegede, Temidayo Abe, Bivek Wagle, Ky Huynh, Dolphurs Hayes, Martin Luther Campbell, Kenechukwu Mezue, Pradhum Ram, Shirley I Nwokike and 7 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cardiovascular disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Obiora EgbucheDivision of Cardiovascular Disease, Morehouse School of Medicine Atlanta, GA 30310, USA.
Opeyemi JegedeDepartment of Biostatistics and Epidemiology, University of North Texas Health Science Center Fort-Worth, TX 76107, USA.
Temidayo AbeDepartment of Internal Medicine, Morehouse School of Medicine Atlanta, GA 30310, USA.
Bivek WagleDepartment of Internal Medicine, Morehouse School of Medicine Atlanta, GA 30310, USA.
Ky HuynhDepartment of Internal Medicine, Morehouse School of Medicine Atlanta, GA 30310, USA.
Dolphurs HayesDepartment of Internal Medicine, Morehouse School of Medicine Atlanta, GA 30310, USA.
Martin Luther CampbellDepartment of Internal Medicine, Morehouse School of Medicine Atlanta, GA 30310, USA.
Kenechukwu MezueDivision of Nuclear Cardiology, Massachusetts General Hospital, Harvard Medical School Boston, MA 02114, USA.
Pradhum RamDivision of Cardiovascular Disease, Emory University School of Medicine Atlanta, GA 30322, USA.
Shirley I NwokikeDepartment of Internal Medicine, Medical College of Georgia Augusta, GA 30912, USA.
Rupak DesaiDivision of Cardiovascular Disease, Atlanta VA Medical Center Decatur, GA 30033, USA.
Valery EffoeDivision of Cardiovascular Disease, Morehouse School of Medicine Atlanta, GA 30310, USA.
Jacques KpodonuDivision of Cardiac Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, MA 02215, USA.
Jayne MorganDivision of Quality and Safety, Piedmont Healthcare, Inc. Atlanta, GA 30309, USA.
Elizabeth OfiliDivision of Cardiovascular Disease, Morehouse School of Medicine Atlanta, GA 30310, USA.
Anekwe OnwuanyiDivision of Cardiovascular Disease, Morehouse School of Medicine Atlanta, GA 30310, USA.
Melvin R EcholsDivision of Cardiovascular Disease, Morehouse School of Medicine Atlanta, GA 30310, USA.
Morehouse School of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Corona Virus 19 (COVID-19) infection is associated with worse outcomes in blacks, although the mechanisms are unclear. We sought to determine the significance of black race, pre-existing cardiovascular disease (pCVD), and acute kidney injury (AKI) on cardiopulmonary outcomes and in-hospital mortality of COVID-19 patients.

methodsWe conducted a retrospective cohort study of blacks with/without pCVD and with/without in-hospital AKI, hospitalized within Grady Memorial Hospital in Georgia between February and July 2020, who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on qualitative polymerase-chain-reaction assay. The primary outcome was a composite of in-hospital cardiac events.

resultsOf the 293 patients hospitalized with COVID-19 in this study, 71 were excluded from the primary analysis (for race/ethnicity other than black non-Hispanic). Of the 222 hospitalized COVID-19 patients included in our analyses, 41.4% were female, 78.8% had pCVD, and 30.6% developed AKI during the admission. In multivariable analyses, pCVD (OR 4.7, 95% CI 1.5-14.8, P=0.008) and AKI (OR 2.7, 95% CI 1.3-5.5, P=0.006) were associated with increased odds of in-hospital cardiac events. AKI was associated with increased odds of in-hospital mortality (OR 8.9, 95% CI 3.3-23.9, P<0.0001). The presence of AKI was associated with increased odds of ICU stay, mechanical ventilation, and acute respiratory distress syndrome (ARDS).

conclusionpCVD and AKI were associated with higher risk of in-hospital cardiac events, and AKI was associated with a higher risk of in-hospital mortality in blacks.

Indexed as

acute kidney injuryblacksCOVID-19mortalityPre-existing CVD

Identifiers

PMID34084656
PMCPMC8166582
OpenAlexW3159264397

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.