Evidence map›Paper›PMID 34084502›Full record

ArticleClinical case reports2021

A case series of serious and unexpected adverse drug reactions under treatment with cariprazine.

Johannes Heck, Johanna Seifert, Dirk O Stichtenoth, Christoph Schroeder, Adrian Groh, Gregor R Szycik, Detlef Degner, Ivana Adamovic, Michael Schneider, Catherine Glocker and 4 more

Abstract readCase Reports
In one paragraph

Article in Clinical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Johannes HeckInstitute for Clinical Pharmacology Hannover Medical School Hannover Germany.ORCID https://orcid.org/0000-0002-5382-3014
Johanna SeifertDepartment of Psychiatry Social Psychiatry and Psychotherapy Hannover Medical School Hannover Germany.ORCID https://orcid.org/0000-0002-8678-7419
Dirk O StichtenothInstitute for Clinical Pharmacology Hannover Medical School Hannover Germany.
Christoph SchroederInstitute for Clinical Pharmacology Hannover Medical School Hannover Germany.
Adrian GrohDepartment of Psychiatry Social Psychiatry and Psychotherapy Hannover Medical School Hannover Germany.ORCID https://orcid.org/0000-0002-4407-3557
Gregor R SzycikDepartment of Psychiatry Social Psychiatry and Psychotherapy Hannover Medical School Hannover Germany.
Detlef DegnerDepartment of Psychiatry and Psychotherapy Georg August University of Göttingen Göttingen Germany.
Ivana AdamovicDepartment of Psychiatry and Psychotherapy Georg August University of Göttingen Göttingen Germany.
Michael SchneiderUniversity Clinic for Psychiatry and Psychotherapy Brandenburg Medical School Immanuel Klinik Rüdersdorf Germany.ORCID https://orcid.org/0000-0002-3275-294X
Catherine GlockerDepartment of Psychiatry and Psychotherapy Ludwig Maximilian University of Munich Munich Germany.ORCID https://orcid.org/0000-0003-0821-8533
Eckart RütherDepartment of Psychiatry and Psychotherapy Ludwig Maximilian University of Munich Munich Germany.
Stefan BleichDepartment of Psychiatry Social Psychiatry and Psychotherapy Hannover Medical School Hannover Germany.
Renate GrohmannDepartment of Psychiatry and Psychotherapy Ludwig Maximilian University of Munich Munich Germany.
Sermin TotoDepartment of Psychiatry Social Psychiatry and Psychotherapy Hannover Medical School Hannover Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reporting of new or unexpected adverse drug reactions of medicines that are subject to additional monitoring ("black triangle" label), such as the antipsychotic drug cariprazine, is of paramount importance to improve pharmacotherapy safety.

Indexed as

adverse drug reactionscariprazinedopamine supersensitivity psychosisdrug safetyhyperprolactinemia

Identifiers

PMID34084502
PMCPMC8142394

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.