Evidence map›Paper›PMID 34084461›Full record

ArticleClinical kidney journal2021

Chronic kidney disease progression among patients with type 2 diabetes identified in US administrative claims: a population cohort study.

Csaba P Kovesdy, Danielle Isaman, Natalia Petruski-Ivleva, Linda Fried, Michael Blankenburg, Alain Gay, Priscilla Velentgas, Kerstin Folkerts

Abstract read
In one paragraph

Article in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The soluble guanylate cyclase activator runcaciguat significantly improves albuminuria in patients with chronic kidney disease: a randomized placebo-controlled clinical trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
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  14. High unmet treatment needs in patients with chronic kidney disease and type 2 diabetes: real-world evidence from a US claims database.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Csaba P KovesdyDepartment of Medicine, Division of Nephrology, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID https://orcid.org/0000-0002-8204-911X
Danielle IsamanDepartment of Science, Aetion Inc., Boston, MA, USA.
Natalia Petruski-IvlevaDepartment of Science, Aetion Inc., Boston, MA, USA.
Linda FriedDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Michael BlankenburgMedical Affairs & Pharmacovigilance, Pharmaceuticals, Bayer AG, Berlin, Germany.
Alain GayMedical Affairs & Pharmacovigilance, Pharmaceuticals, Bayer AG, Berlin, Germany.
Priscilla VelentgasDepartment of Science, Aetion Inc., Boston, MA, USA.
Kerstin FolkertsMarket Access, Public Affairs & Sustainability, HEOR CV, Bayer AG, Wuppertal, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD), one of the most common complications of type 2 diabetes (T2D), is associated with poor health outcomes and high healthcare expenditures. As the CKD population increases, a better understanding of the prevalence and progression of CKD is critical. However, few contemporary studies have explored the progression of CKD relative to its onset in T2D patients using established markers derived from real-world care settings.

methodsThis retrospective, population-based cohort study assessed CKD progression among adults with T2D and with newly recognized CKD identified from US administrative claims data between 1 January 2008 and 30 September 2018. Included were patients with T2D and laboratory evidence of CKD as indicated by the established estimated glomerular filtration rate (eGFR) and urine albumin:creatinine ratio (UACR) criteria. Disease progression was described as transitions across the eGFR- and UACR-based stages.

resultsA total of 65 731 and 23 035 patients with T2D contributed to the analysis of eGFR- and UACR-based CKD stage progression, respectively. CKD worsening was observed in approximately 10-17% of patients over a median follow-up of 2 years. Approximately one-third of patients experienced an increase in eGFR values or a decrease in UACR values during follow-up.

conclusionsA relatively high proportion of patients were observed with disease progression over a short period of time, highlighting the need for better identification of patients at risk of rapidly progressive CKD. Future studies are needed to determine the clinical characteristics of these patients to inform earlier diagnostic and therapeutic interventions aimed at slowing disease progression.

Indexed as

chronic kidney diseasedisease progressioneGFRreal-world datatype 2 diabetesUACR

Identifiers

PMID34084461
PMCPMC8162850

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.