ArticleChemical science2019
A near-infrared fluorescent probe reveals decreased mitochondrial polarity during mitophagy.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 153 citations in OpenAlex.
- The endoplasmic reticulum displays high polarity with low protein aggregation in human cells.Communications biology · 2026Article
- Organic Fluorophores Conjugated with Pyridinium Acceptor: A Review on Design, Synthesis, and Application in Mitochondrial Imaging.Current pharmaceutical design · 2026Review
- Illuminating Mitochondrial Dynamics: Ultrahigh Labeling Stability Probe for Long-Term SIM Super-Resolution Imaging of Mitochondria.ACS central science · 2025Article
- Spatiotemporal Super-Resolution Imaging of Lipid Metabolism Dynamics in Physiological/Pathological Conditions.Angewandte Chemie (International ed. in English) · 2025Article
- A Novel Near-Infrared Tricyanofuran-Based Fluorophore Probe for Polarity Detection and LD Imaging.Molecules (Basel, Switzerland) · 2024Article
- Development of Dual-Responsive Fluorescent Probe for Drug Screening of Diabetes Cardiomyopathy.Chemical & biomedical imaging · 2024Article
- Monitoring Cell Plasma Membrane Polarity by a NIR Fluorescence Probe with Unexpected Cell Plasma Membrane-Targeting Ability.ACS omega · 2022Article
- Activity-Based Fluorescent Probes Based on Hemicyanine for Biomedical Sensing.Molecules (Basel, Switzerland) · 2022Review
- High-fidelity carbon dots polarity probes: revealing the heterogeneity of lipids in oncology.Light, science & applications · 2022Article
- Fluorescent Probes Design Strategies for Imaging Mitochondria and Lysosomes.Frontiers in pharmacology · 2022Review
- Iridium(III) complexes with 1-phenylisoquinoline-4-carbonitrile units for efficient NIR organic light-emitting diodes.iScience · 2021Article
- An Enumerated Outlook of Intracellular Micropolarity Using Solvatochromic Organic Fluorescent Probes.ACS omega · 2021Review
- A self-immobilizing near-infrared fluorogenic probe for sensitive imaging of extracellular enzyme activityChemical science · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitophagy is a selective form of autophagy by which dysfunctional and damaged mitochondria are degraded in autolysosomes. Since defective mitophagy is closely related to various pathological processes, investigation on the detailed mitophagy process is of great importance. In this respect, disclosing the alterations of mitochondrial microenvironments is expected to be a promising way. However, an appropriate method for monitoring the fluctuations of mitochondrial polarity during mitophagy is still lacking. Here, we report a near-infrared hydroxyl-hemicyanine fluorescent probe that responds to polarity exclusively. Both the shift of emission maxima and the fluorescence intensity ratios at two different wavelengths of the probe can be applied to quantifying the polarity accurately. With ratiometric fluorescence imaging, the polarity differences of normal and cancer cells are clearly discriminated. Most importantly, the mitochondrial polarity variations during starvation and drug-induced mitophagy are determined for the first time. The observed decrease of mitochondrial polarity during mitophagy, together with the rationally designed probe, may facilitate the study on the vital role of mitophagy in physiological and pathological bioprocesses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.