Evidence map›Paper›PMID 34084324›Full record

ArticleChemical science2020

Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer.

Nancy Soliman, Luke K McKenzie, Johannes Karges, Emilie Bertrand, Mickaël Tharaud, Marta Jakubaszek, Vincent Guérineau, Bruno Goud, Marcel Hollenstein, Gilles Gasser and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 47 citations in OpenAlex.

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  14. Critical discussion of the applications of metal complexes for 2-photon photodynamic therapy.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Nancy SolimanChimie ParisTech, PSL University, CNRS, Institut de Recherche de Chimie Paris 75005 Paris France christophe.thomas@chimie-paristech.fr.ORCID https://orcid.org/0000-0002-3031-8584
Luke K McKenzieChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology 75005 Paris France gilles.gasser@chimieparistech.psl.eu.ORCID https://orcid.org/0000-0002-0955-9447
Johannes KargesChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology 75005 Paris France gilles.gasser@chimieparistech.psl.eu.ORCID https://orcid.org/0000-0001-5258-0260
Emilie BertrandChimie ParisTech, PSL University, CNRS, Institut de Recherche de Chimie Paris 75005 Paris France christophe.thomas@chimie-paristech.fr.
Mickaël TharaudUniversité de Paris, Institut de Physique du Globe de Paris, CNRS 75005 Paris France.ORCID https://orcid.org/0000-0001-6131-655X
Marta JakubaszekChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology 75005 Paris France gilles.gasser@chimieparistech.psl.eu.ORCID https://orcid.org/0000-0001-7590-2330
Vincent GuérineauInstitut de Chimie des Substances Naturelles, CNRS UPR2301, Université Paris-Sud, Université Paris-Saclay Avenue de la Terrasse 91198 Gif-sur-Yvette Cedex France.
Bruno GoudInstitut Curie, PSL University, CNRS UMR 144 75005 Paris France.ORCID https://orcid.org/0000-0003-1227-4159
Marcel HollensteinInstitut Pasteur, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, CNRS UMR 3523 75015 Paris France.ORCID https://orcid.org/0000-0003-0263-9206
Gilles GasserChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology 75005 Paris France gilles.gasser@chimieparistech.psl.eu.ORCID https://orcid.org/0000-0002-4244-5097
Christophe M ThomasChimie ParisTech, PSL University, CNRS, Institut de Recherche de Chimie Paris 75005 Paris France christophe.thomas@chimie-paristech.fr.ORCID https://orcid.org/0000-0001-8014-4255
Centre National de la Recherche Scientifique · FRInstitut de physique du globe de Paris · FRUniversité Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ruthenium complexes have attracted a lot of attention as potential photosensitizers (PSs) for photodynamic therapy (PDT). However, some of these PSs are unsuitable for PDT applications due to their low cellular uptake, which is possibly the consequence of their relatively low degree of lipophilicity, which prevents them from penetrating into tumor cells. Here, we report the simple one-pot synthesis of ruthenium-containing nanoconjugates from a non-cell-penetrating, non-phototoxic ruthenium(ii) polypyridyl complex (

Identifiers

PMID34084324
PMCPMC8157674
OpenAlexW3004352940

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.