ArticleInternational journal of preventive medicine2021
Protective Role of Angiotensin II Type 1 Receptor Blocker on Short Time Effect of Oleic Acid Induced Lung and Kidney Injury.
Article in International journal of preventive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Natural compounds targeting inflammatory signaling and cell adhesion molecules in ischemic acute kidney injury.Archives of pharmacal research · 2026Review
- Role of local angiotensin II signaling in bladder function.American journal of physiology. Renal physiology · 2024Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundsAcute respiratory distress syndrome (ARDS) causes high mortality rate in clinic, and the pathogenesis of this syndrome may interact with renin angiotensin system (RAS) components. The main objective of this study was to determine the protective role of AT1R antagonist (losartan) on oleic acid (OA) induced ARDS and kidney injury.
methodsThe animal model of ARDS was performed by intravenous administration of 250 μl/kg oleic acid (OA). Male and female rats were subjected to received intravenously vehicle (saline, groups 1 and 4), OA (groups 2 and 5), or losartan (10 mg/kg) plus OA (groups 3 and 6), and six hour later, the measurements were performed.
resultsCo-treatment of OA and losartan increased the serum levels of blood urea nitrogen significantly (
conclusionsLosartan may protect the kidney and lung against OA induced tissue injury in male rats. This protective action is not certain in female rats.
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