Evidence map›Paper›PMID 34084212›Full record

ArticleLung cancer management2021

Treatment and outcomes for early non-small-cell lung cancer: a retrospective analysis of a Portuguese hospital database.

Marta Soares, Luís Antunes, Patrícia Redondo, Marina Borges, Ruben Hermans, Dony Patel, Fiona Grimson, Robin Munro, Carlos Chaib, Laure Lacoin and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Lung cancer management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
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  11. Future oncology (London, England) · 2024
    Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Marta SoaresDepartment of Medical Oncology, Portuguese Oncology Institute of Porto (IPO-Porto), 4200-072 Porto, Portugal.ORCID https://orcid.org/0000-0002-6071-3673
Luís AntunesCancer Epidemiology Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), 4200-072 Porto, Portugal.ORCID https://orcid.org/0000-0002-3098-0711
Patrícia RedondoOutcomes Research Lab, Portuguese Oncology Institute of Porto (IPO-Porto), 4200-072 Porto, Portugal.ORCID https://orcid.org/0000-0001-8560-1646
Marina BorgesOutcomes Research Lab, Portuguese Oncology Institute of Porto (IPO-Porto), 4200-072 Porto, Portugal.ORCID https://orcid.org/0000-0002-8073-6506
Ruben HermansReal World Solutions, IQVIA, London, N1 9JY, UK.
Dony PatelReal World Solutions, IQVIA, London, N1 9JY, UK.
Fiona GrimsonReal World Solutions, IQVIA, London, N1 9JY, UK.
Robin MunroReal World Solutions, IQVIA, London, N1 9JY, UK.
Carlos ChaibR&D Medical Affairs, Bristol Myers Squibb, 28050 Madrid, Spain.
Laure LacoinWorldwide Health Economics & Outcomes Research, Bristol Myers Squibb, 1420 Braine-l'Alleud, Belgium.
Melinda DaumontWorldwide Health Economics & Outcomes Research, Bristol Myers Squibb, 1420 Braine-l'Alleud, Belgium.ORCID https://orcid.org/0000-0002-4319-1498
John R PenrodWorldwide Health Economics & Outcomes Research, Bristol Myers Squibb, Princeton, NJ 08540, USA.
John C O'DonnellWorldwide Health Economics & Outcomes Research, Bristol Myers Squibb, Princeton, NJ 08540, USA.
Maria José BentoCancer Epidemiology Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), 4200-072 Porto, Portugal.ORCID https://orcid.org/0000-0002-7690-9830
Francisco Rocha GonçalvesMEDCIDS, Faculty of Medicine, University of Porto, 4200-450 Porto, Portugal.
Instituto Português de Oncologia Francisco Gentil · PTIQVIA (United Kingdom) · GBBristol-Myers Squibb (Belgium) · BEBristol-Myers Squibb (United States) · USUniversidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis observational study evaluated treatment patterns and survival for patients with stage I-IIIA non-small-cell lung cancer (NSCLC). MATERIALS &

methodsAdults newly diagnosed with NSCLC in 2012-2016 at IPO-Porto hospital were included. Treatment data were available for patients diagnosed in 2015-2016.

results495 patients were included (median age: 67 years). The most common treatments were surgery alone or with another therapy (stage I: 66%) and systemic anticancer therapy plus radiotherapy (stage II: 54%; stage IIIA: 59%). One-year OS (95% CI) for patients with stage I, II and IIIA NSCLC (diagnosed 2012-2016) were 92% (88-96), 71% (62-82) and 69% (63-75), respectively; one-year OS (95% CI) for treated patients with stage I-II or stage IIIA NSCLC (diagnosed 2015-2016) were 89% (81-97) and 86% (75-98) for non-squamous cell and 76% (60-95) and 49% (34-70) for squamous cell NSCLC.

conclusionTreatment advances are strongly needed for stage I-IIIA NSCLC, especially for patients with squamous cell histology.

Indexed as

non-small-cell lung cancernon-squamous cell carcinomaoverall survivalreal-world evidencesquamous cell carcinomastage I–IIIAtreatment patterns

Identifiers

PMID34084212
PMCPMC8162184
OpenAlexW3130447763

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.