ArticleResearch in pharmaceutical sciences2021
Expression of cyclin D1, p21, and estrogen receptor alpha in aflatoxin G1-induced disturbance in testicular tissue of albino mice.
Article in Research in pharmaceutical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Aflatoxin Exposure-Caused Male Reproductive Toxicity: Molecular Mechanisms, Detoxification, and Future Directions.Biomolecules · 2024Review
- Oral administration of crocin-loaded solid lipid nanoparticles inhibits neuroinflammation in a rat model of epileptic seizures by activating SIRT1 expression.Research in pharmaceutical sciences · 2024Article
- Application of Biosensors for the Detection of Mycotoxins for the Improvement of Food Safety.Toxins · 2024Review
- A Metabolomic Analysis to Assess the Responses of the Male Gonads ofMetabolites · 2023Article
- The histopathological changes of liver and testis of Japanese quail chicks fed different levels of dietary L-valine.Veterinary and animal science · 2023Article
- ERα promotesGland surgery · 2023Article
- Single intratesticular injection of blood-serum-derived exosomes can potentially alleviate testopathy following testicular torsion.Animal models and experimental medicine · 2022Article
- Aflatoxin G1 exposure altered the expression of BDNF and GFAP, histopathological of brain tissue, and oxidative stress factors in male rats.Research in pharmaceutical sciences · 2022Article
- Apigeninidin-enrichedExperimental biology and medicine (Maywood, N.J.) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAflatoxin (AF) is a mycotoxin produced by various strains of the EXPERIMENTAL APPROACH: Twenty-four Albino mice were divided into four groups of 6 each; a control group (0.2 mL corn oil and ethanol), three treatment groups with different periods (20 μg/kg AFG1 for 7, 15, and 35 consecutive days). All treatments were applied intraperitoneally. Biosynthesis of cyclin D1, p21, and estrogen receptor alpha (ERα) proteins was evaluated by immunohistochemistry (IHC) staining. Levels of cyclin D1, p21, and ERα mRNA were evaluated by the real-time polymerase chain reaction (RT-PCR) technique. Tubular differentiation index (TDI), reproductive index (RI), and spermiogenesis indices were also analyzed. FINDINGS/
resultsAFG1 increased the percentage of seminiferous tubules with negative TDI, RI, and SPI compared to the control group ( CONCLUSION AND IMPLICATIONS: The chronic exposure to AFG1 reduced the expression and synthesis of ERα, increased the expression and synthesis of p21 and cyclin D1, impaired apoptosis, which in turn could impair spermatogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.