Evidence map›Paper›PMID 34084151›Full record

Observational studyFrontiers in endocrinology2021

Nuclear Magnetic Resonance Derived Biomarkers for Evaluating Cardiometabolic Risk in Youth and Young Adults Across the Spectrum of Glucose Tolerance.

Stephanie T Chung, Samantha T Matta, Abby G Meyers, Celeste K Cravalho, Alfredo Villalobos-Perez, Joshua M Dawson, Vandhna R Sharma, Maureen L Sampson, James D Otvos, Sheela N Magge

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Observational
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Stephanie T ChungDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Samantha T MattaDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Abby G MeyersDepartment of Endocrinology and Diabetes, Children's National Hospital, Washington, DC, United States.
Celeste K CravalhoDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Alfredo Villalobos-PerezDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Joshua M DawsonDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Vandhna R SharmaDiabetes, Endocrinology and Obesity Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Maureen L SampsonNational Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD, United States.
James D OtvosLaboratory Corporation of America Holdings (LabCorp), Morrisville, NC, United States.
Sheela N MaggeDivision of Pediatric Endocrinology and Diabetes, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
National Institutes of Health · USNational Institute of Diabetes and Digestive and Kidney Diseases · USChildren's National · USJohns Hopkins University · USLabCorp (United States) · USNational Institutes of Health Clinical Center · US

Funding

Therapeutic targets in African-American youth with type 2 diabetesZIADK075133 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CHUNG, STEPHANIE THERESE · 2016 to 2025
$5.8M
6 · The paper itself

Abstract

Youth with obesity have an increased risk for cardiometabolic disease, but identifying those at highest risk remains a challenge. Four biomarkers that might serve this purpose are "by products" of clinical NMR LipoProfile Clinical Trial Registration: Clinicaltrials.gov, identifier NCT:02960659.

Indexed as

Insulin ResistanceAdolescentAdultAmino Acids, Branched-ChainBiomarkersBlood GlucoseCardiovascular DiseasesCase-Control StudiesDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHumansLipoproteinsMagnetic Resonance SpectroscopyMaleObesityAmino Acids, Branched-ChainBiomarkersBlood GlucoseLipoproteinscardiometabolic riskglucose toleranceGlycAinsulin resistancelipoprotein insulin resistance indexNMRyouth

Identifiers

PMID34084151
PMCPMC8167058
OpenAlexW3161389637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.