Evidence map›Paper›PMID 34084149›Full record

ReviewFrontiers in endocrinology2021

Leptin and Obesity: Role and Clinical Implication.

Milan Obradovic, Emina Sudar-Milovanovic, Sanja Soskic, Magbubah Essack, Swati Arya, Alan J Stewart, Takashi Gojobori, Esma R Isenovic

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 596 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
596citing papers in PubMed, 6 pooled it
64.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

596 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,012 citations in OpenAlex.

  1. Pooled it
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  7. Trial
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  11. Gut microbes · 2026
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  18. Healing mechanisms of Galectin-1 in the ischemic heart.Cell biochemistry and biophysics · 2026
    Review
  19. Amylin: A Multi-Functional Pancreatic Hormone-A Review.Diabetes, obesity & metabolism · 2026
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  20. Article

536 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Milan ObradovicDepartment of Radiobiology and Molecular Genetics, "VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Emina Sudar-MilovanovicDepartment of Radiobiology and Molecular Genetics, "VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Sanja SoskicDepartment of Radiobiology and Molecular Genetics, "VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Magbubah EssackComputer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), Computational Bioscience Research Center, Computer (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Swati AryaSchool of Medicine, University of St Andrews, St Andrews, United Kingdom.
Alan J StewartSchool of Medicine, University of St Andrews, St Andrews, United Kingdom.
Takashi GojoboriComputer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), Computational Bioscience Research Center, Computer (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Esma R IsenovicDepartment of Radiobiology and Molecular Genetics, "VINČA" Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
University of Belgrade · RSKing Abdullah University of Science and Technology · SAUniversity of St Andrews · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. Leptin is a product of the obese (

Indexed as

AnimalsEnergy MetabolismHumansHypothalamusLeptinObesityRisk FactorsSatiety ResponseSignal TransductionLeptinleptinleptin-based therapiesleptin receptorleptin resistanceobesity

Identifiers

PMID34084149
PMCPMC8167040
OpenAlexW3161404038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.