ArticleJournal of cutaneous and aesthetic surgery
Fractional Carbon Dioxide Laser versus Combined Fractional Carbon Dioxide Laser with Platelet-rich Plasma in the Treatment of Atrophic Post-acne Scars: A Split-face Comparative Study.
Article in Journal of cutaneous and aesthetic surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Laser, Microneedling, and Combination Therapies for Moderate to Severe Acne Atrophic Scars: A Systematic Review and Network Meta-Analysis.Aesthetic plastic surgery · 2026Pooled it
- Platelet-rich plasma and ablative fractional carbon dioxide laser therapy for chronic scar management: a systematic review.Lasers in medical science · 2026Pooled it
- Minimally invasive interventions for atrophic acne scars: a PubMed/PMC-based systematic evidence review and exploratory network meta-analysis toward phenotype-guided interpretation.Frontiers in surgery · 2026Pooled it
- TFOS Lifestyle: Impact of cosmetics on the ocular surface.The ocular surface · 2023Pooled it
- A Randomized Controlled Trial of Platelet-Rich Plasma Combined with Fractional COInternational urogynecology journal · 2026Trial
- Fractional COLasers in medical science · 2025Trial
- Berberine Inhibits Acne-Related Lipid Secretion and Inflammation by Regulating the hsa-miR-3150a-3p/TP53 Pathway.Journal of inflammation research · 2025Article
- A Network Meta-analysis to Explore the Effectiveness of the Different Treatment Modalities in Acne Scars.Aesthetic plastic surgery · 2024Review
- Dermatology: how to manage acne vulgaris.Drugs in context · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThough many treatment options are available for treating post-acne scars, optimized treatment still does not exist. Till date, comparative split-face studies, analyzing the efficacy of combined treatment modalities for acne scars with adequate sample size and with statistically significant results, are still lacking.
aimThe aim of this study was to compare the effectiveness of the combined use of platelet-rich plasma (PRP) and fractional ablative CO SETTINGS AND
designThis was a randomized split-face trial study. MATERIALS AND
methodsThis study was conducted in 30 patients having Goodman and Baron's grade 3 and 4 acne scars. The efficacy of PRP in combination with FACL was compared to FACL alone in the treatment of post-acne scars. Right half of the patient's face was taken as the study side where FACL was performed followed by PRP injections. The left half of the same patient's face was taken as the control side where FACL was performed followed by normal saline injections. STATISTICAL ANALYSIS: Results were analyzed using Statistical Package for the Social Sciences (SPSS, Chicago).
resultsAt the time of enrollment, mean Goodman and Baron Acne Qualitative Grading Scale on study and control side was 3.80 with standard deviation (SD) of 0.40 at baseline. After completion of four treatment sessions, it was reduced to 2.43 (SD = 0.76) and 2.76 (SD = 0.49) on the study and control side, respectively. Improvement on both sides was statistically significant (
conclusionThere is no single proven modality for the effective treatment of post-acne scars. Combination of FACL with newer adjuvants such as PRP has definitive role in managing post-acne scars with better safety profile than FACL alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.