Evidence map›Paper›PMID 34083845›Full record

ArticleJournal of research in personality2021

A coordinated analysis of the associations among personality traits, cognitive decline, and dementia in older adulthood.

Eileen K Graham, Bryan D James, Kathryn L Jackson, Emily C Willroth, Jing Luo, Christopher R Beam, Nancy L Pedersen, Chandra A Reynolds, Mindy Katz, Richard B Lipton and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of research in personality, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Personality trait and state associations with cognitive functioning and variability in middle-aged and older adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  5. Article
  6. A Taxonomy of Data Synthesis.Personality & social psychology bulletin · 2026
    Article
  7. Article
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  14. Article
  15. Personality and Cognition: The Mediating Role of Inflammatory Markers.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
    Article
  16. Article
  17. Article
  18. Neuroticism and white matter hyperintensities.Journal of psychiatric research · 2023
    Article
  19. Article
  20. Associations Between Loneliness and Cognitive Resilience to Neuropathology in Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Eileen K GrahamNorthwestern University.
Bryan D JamesRush University Medical Center.
Kathryn L JacksonNorthwestern University.
Emily C WillrothNorthwestern University.
Jing LuoNorthwestern University.
Christopher R BeamUniversity of Southern California.
Nancy L PedersenKarolinska Institute.
Chandra A ReynoldsUniversity of California, Riverside.
Mindy KatzAlbert Einstein College of Medicine.
Richard B LiptonAlbert Einstein College of Medicine.
Patricia BoyleRush University Medical Center.
Robert WilsonRush University Medical Center.
David A BennettRush University Medical Center.
Daniel K MroczekNorthwestern University.
Northwestern University · USRush University Medical Center · USAlbert Einstein College of Medicine · USKarolinska Institutet · SEUniversity of California, Riverside · USUniversity of Southern California · US

Funding

Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI Richard B. LIPTON · 1985 to 2026
$73.9M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
PERSONALITY AND WELL BEING TRAJECTORIES IN ADULTHOODR01AG018436 · NIA · PURDUE UNIVERSITY WEST LAFAYETTE · PI MROCZEK, DANIEL K. · 2000 to 2020
$6.7M
Personality prediction of dementia risk and progressionR01AG067622 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MROCZEK, DANIEL K. · 2019 to 2023
$3.2M
Cognitive decline after hospitalization in older adults: predictors and pathogenesisK01AG050823 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI JAMES, BRYAN DAVID · 2015 to 2019
$580k
NIA NIH HHS K01 AG050823NIA NIH HHS P01 AG003949NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG018436NIA NIH HHS R01 AG067622
6 · The paper itself

Abstract

There are individual differences in the rates of cognitive decline across later adulthood. Personality traits are among the factors that may account for these differences. The current project investigated whether personality traits were associated with trajectories of cognitive decline, and whether the associations were different before and after dementia diagnosis. The data was analyzed using linear mixed effects regression. Across study aims is a focus on replicability and generalizability. Each question was addressed in four independent longitudinal studies (EAS, MAP, ROS, SATSA), then meta-analyzed, providing estimates of replicability. Results indicated that low neuroticism and high openness were associated with total cognitive function. We detected evidence for cognitive decline in all four samples, and openness was associated with decline post dementia diagnosis.

Identifiers

PMID34083845
PMCPMC8168939
OpenAlexW3158507945

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.