ArticleNature neuroscience2021
Collicular circuits for flexible sensorimotor routing.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Hippocampal engrams configure prefrontal context representations to guide flexible decisions.bioRxiv : the preprint server for biology · 2026Article
- The geometry of context-dependent biased decisions during learning.bioRxiv : the preprint server for biology · 2026Article
- Brain-wide analysis reveals movement encoding structured across and within brain areas.Nature neuroscience · 2026Article
- Brain-wide coordination of internal signals during decision-making.bioRxiv : the preprint server for biology · 2025Article
- Article
- Cholecystokinin neurons in the spinal trigeminal nucleus interpolaris regulate mechanically evoked predatory hunting in male mice.Nature communications · 2025Article
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- Latent circuit inference from heterogeneous neural responses during cognitive tasks.Nature neuroscience · 2025Article
- Genetically defined neuron types underlying visuomotor transformation in the superior colliculus.Nature reviews. Neuroscience · 2024Review
- Primate superior colliculus is causally engaged in abstract higher-order cognition.Nature neuroscience · 2024Article
- Task interference as a neuronal basis for the cost of cognitive flexibility.bioRxiv : the preprint server for biology · 2024Article
- Article
- Article
- Superior colliculus bidirectionally modulates choice activity in frontal cortex.Nature communications · 2023Article
- Neural mechanisms for the localization of unexpected external motion.Nature communications · 2023Article
- Pathway-specific inputs to the superior colliculus support flexible responses to visual threat.Science advances · 2023Article
- Bias in Prestimulus Motor Cortical Activity Determines Decision-making Error in Rodents.Experimental neurobiology · 2023Article
- A unifying perspective on neural manifolds and circuits for cognition.Nature reviews. Neuroscience · 2023Review
- Superior colliculus cell types bidirectionally modulate choice activity in frontal cortex.bioRxiv : the preprint server for biology · 2023Article
- A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions.Nature communications · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Context-based sensorimotor routing is a hallmark of executive control. Pharmacological inactivations in rats have implicated the midbrain superior colliculus (SC) in this process. But what specific role is this, and what circuit mechanisms support it? Here we report a subset of rat SC neurons that instantiate a specific link between the representations of context and motor choice. Moreover, these neurons encode animals' choice far earlier than other neurons in the SC or in the frontal cortex, suggesting that their neural dynamics lead choice computation. Optogenetic inactivations revealed that SC activity during context encoding is necessary for choice behavior, even while that choice behavior is robust to inactivations during choice formation. Searches for SC circuit models matching our experimental results identified key circuit predictions while revealing some a priori expected features as unnecessary. Our results reveal circuit mechanisms within the SC that implement response inhibition and context-based vector inversion during executive control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.