Evidence map›Paper›PMID 34083624›Full record

ArticleScientific reports2021

Hemodynamic and biological correlates of glomerular hyperfiltration in sickle cell patients before and under renin-angiotensin system blocker.

Jean-Philippe Haymann, Nadjib Hammoudi, Marine Livrozet, Aline Santin, Sarah Mattioni, Emmanuel Letavernier, Vincent Frochot, Camille Saint Jacques, Olivier Steichen, Gilles Grateau and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Sickle Cell Disease and CKD: An Update.American journal of nephrology · 2024
    Review
  10. Glomerular hyperfiltration: part 2-clinical significance in children.Pediatric nephrology (Berlin, Germany) · 2023
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jean-Philippe HaymannService d'Explorations Fonctionnelles Multidisciplinaires, AP-HP, Hôpital Tenon, Sorbonne Université, 75020, Paris, France. jean-philippe.haymann@aphp.fr.
Nadjib HammoudiINSERM, Institute of Cardiometabolism and Nutrition (ICAN), ACTION Study Group and Department of Cardiology, Institute of Cardiology (AP-HP), Hôpital Pitié-Salpêtrière, Sorbonne Université, Boulevard de l'hôpital, 75013, Paris, France.
Marine LivrozetService d'Explorations Fonctionnelles Multidisciplinaires, AP-HP, Hôpital Tenon, Sorbonne Université, 75020, Paris, France.
Aline SantinDepartment of Internal Medicine, Centre de reference de la drepanocytose (AP-HP), Centre Hospitalier Universitaire Tenon, Sorbonne Université, rue de la Chine, 75020, Paris, France.
Sarah MattioniDepartment of Internal Medicine, Centre de reference de la drepanocytose (AP-HP), Centre Hospitalier Universitaire Tenon, Sorbonne Université, rue de la Chine, 75020, Paris, France.
Emmanuel LetavernierService d'Explorations Fonctionnelles Multidisciplinaires, AP-HP, Hôpital Tenon, Sorbonne Université, 75020, Paris, France.
Vincent FrochotService d'Explorations Fonctionnelles Multidisciplinaires, AP-HP, Hôpital Tenon, Sorbonne Université, 75020, Paris, France.
Camille Saint JacquesService d'Explorations Fonctionnelles Multidisciplinaires, AP-HP, Hôpital Tenon, Sorbonne Université, 75020, Paris, France.
Olivier SteichenDepartment of Internal Medicine, Centre de reference de la drepanocytose (AP-HP), Centre Hospitalier Universitaire Tenon, Sorbonne Université, rue de la Chine, 75020, Paris, France.
Gilles GrateauDepartment of Internal Medicine, Centre de reference de la drepanocytose (AP-HP), Centre Hospitalier Universitaire Tenon, Sorbonne Université, rue de la Chine, 75020, Paris, France.
Michel ChaignonService d'Explorations Fonctionnelles Multidisciplinaires, AP-HP, Hôpital Tenon, Sorbonne Université, 75020, Paris, France.
François LionnetDepartment of Internal Medicine, Centre de reference de la drepanocytose (AP-HP), Centre Hospitalier Universitaire Tenon, Sorbonne Université, rue de la Chine, 75020, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glomerular hyperfiltration alone or associated with albuminuria is a well-known feature of sickle cell associated nephropathy. Though, glomerular hyperfiltration is currently considered to be related to a high renal plasma flow and chronic hemolysis, cardiac output influence on measured glomerular filtration rate (mGFR) have not been investigated so far. Thirty seven homozygous sickle cell patients (SCA) from the RAND study investigated before and under angiotensin converting enzyme inhibitor (ACEI) were included. Both mGFR and cardiac index (CI) were high (> 110 ml/min/1.73 m

Indexed as

Glomerular Filtration RateHemodynamicsAdultAnemia, Sickle CellAngiotensin-Converting Enzyme InhibitorsBiomarkersFemaleHumansKidney DiseasesKidney GlomerulusMaleRenin-Angiotensin SystemTreatment OutcomeYoung AdultAngiotensin-Converting Enzyme InhibitorsBiomarkers

Identifiers

PMID34083624
PMCPMC8175337

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.