ArticleNature communications2021
Dating Alphaproteobacteria evolution with eukaryotic fossils.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 65 citations in OpenAlex.
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- Molecular clock dating using complex mixture models: applied to ancient symbionts.Molecular biology and evolution · 2026Article
- Molecular Phylogeny of "Chemosensory Proteins" in Bacteria and Arthropods: CSP as an Extremely Ancient Gene.Journal of molecular evolution · 2026Article
- Noncanonical genetic markers resolve the pre-GOE emergence of aerobic bacteria in Earth's history.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Adaptation of Fe-S Cluster Assembly to Rising OResearch square · 2026Article
- Widespread potential for phototrophy and convergent reduction of lifecycle complexity in the dimorphic order Caulobacterales.Nature communications · 2025Article
- Dating the Bacterial Tree of Life Based on Ancient Symbiosis.Systematic biology · 2025Article
- Hidden Markov Model-Based Prokaryotic Genome Space Mining Reveals the Widespread Pervasiveness of Complex I and Its Potential Evolutionary Scheme.Genome biology and evolution · 2025Article
- An Evolutionary-Focused Review of the Holosporales (Alphaproteobacteria): Diversity, Host Interactions, and Taxonomic Re-ranking as Holosporineae Subord. Nov.Microbial ecology · 2025Review
- Hepatincolaceae (Alphaproteobacteria) are Distinct From Holosporales and Independently Evolved to Associate With Ecdysozoa.Environmental microbiology · 2025Article
- Integrating Mitochondrial Biology into Innovative Cell Therapies for Neurodegenerative Diseases.Brain sciences · 2024Review
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- Addictive manipulation: a perspective on the role of reproductive parasitism in the evolution of bacteria-eukaryote symbioses.Biology letters · 2024Review
- Host-bacteria interactions: ecological and evolutionary insights from ancient, professional endosymbionts.FEMS microbiology reviews · 2024Review
- "Candidatus Intestinibacterium parameciiphilum"-member of the "Candidatus Paracaedibacteraceae" family (Alphaproteobacteria, Holosporales) inhabiting the ciliated protist Paramecium.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Article
- Dating Ammonia-Oxidizing Bacteria with Abundant Eukaryotic Fossils.Molecular biology and evolution · 2024Article
- Lineage-specific evolution ofApplied and environmental microbiology · 2024Article
- Host association and intracellularity evolved multiple times independently in the Rickettsiales.Nature communications · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elucidating the timescale of the evolution of Alphaproteobacteria, one of the most prevalent microbial lineages in marine and terrestrial ecosystems, is key to testing hypotheses on their co-evolution with eukaryotic hosts and Earth's systems, which, however, is largely limited by the scarcity of bacterial fossils. Here, we incorporate eukaryotic fossils to date the divergence times of Alphaproteobacteria, based on the mitochondrial endosymbiosis that mitochondria evolved from an alphaproteobacterial lineage. We estimate that Alphaproteobacteria arose ~1900 million years (Ma) ago, followed by rapid divergence of their major clades. We show that the origin of Rickettsiales, an order of obligate intracellular bacteria whose hosts are mostly animals, predates the emergence of animals for ~700 Ma but coincides with that of eukaryotes. This, together with reconstruction of ancestral hosts, strongly suggests that early Rickettsiales lineages had established previously underappreciated interactions with unicellular eukaryotes. Moreover, the mitochondria-based approach displays higher robustness to uncertainties in calibrations compared with the traditional strategy using cyanobacterial fossils. Further, our analyses imply the potential of dating the (bacterial) tree of life based on endosymbiosis events, and suggest that previous applications using divergence times of the modern hosts of symbiotic bacteria to date bacterial evolution might need to be revisited.
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