ArticleScience (New York, N.Y.)2021
MBD5 and MBD6 couple DNA methylation to gene silencing through the J-domain protein SILENZIO.
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In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
15.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 87 citations in OpenAlex.
- The spliceosome's secret life: pRP8 silences transposons through 3D chromatin organization.The Plant cell · 2026Article
- Maintenance of H3K9me2 heterochromatin in the pollen vegetative nucleus requires ARID1 nuclear body formation.The Plant journal : for cell and molecular biology · 2026Article
- The chromatin reader MBD4 regulates temperature- and flowering-responsive transcription by recognizing histone arginine methylation.Plant communications · 2026Article
- MBD8 is required for LDL2-mediated transcriptional repression downstream of H3K9me2 in Arabidopsis.Nucleic acids research · 2026Article
- Photorespiration is linked to DNA methylation by formate as a one-carbon source.Nature plants · 2026Article
- Multiple redundant mechanisms account for the majority of gene silencing downstream of DNA methylation.bioRxiv : the preprint server for biology · 2026Article
- SHH1 cooperates with the DNA methylation reader MBD7 to suppress transcriptional silencing of promoter-methylated genes in Arabidopsis.Plant communications · 2026Article
- Decoding Dysregulation of DNA Methylation in Epigenetics of Idiopathic Pulmonary Fibrosis.Canadian respiratory journal · 2026Review
- A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis-regulatory Modules.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics.Nature communications · 2025Article
- CRISPR targeting of H3K4me3 activates gene expression and unlocks centromere-proximal crossover recombination in Arabidopsis.Nature communications · 2025Article
- An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics.bioRxiv : the preprint server for biology · 2025Article
- A Novel Intronic Mutation in MBD5 Results in Autosomal Dominant Intellectual Disability Type 1 due to Abnormal Splicing.Molecular genetics & genomic medicine · 2025Article
- Methylation of mycovirus DNA is mediated by the RNAi machinery in vegetative hyphae of Fusarium graminearum.Nucleic acids research · 2025Article
- LEC2 induces somatic cell reprogramming through epigenetic activation of plant cell totipotency regulators.Nature communications · 2025Article
- Expression of thePlants (Basel, Switzerland) · 2025Article
- Heat stress response and transposon control in plant shoot stem cells.Plant physiology · 2025Article
- Roles of methyl-CpG-binding-domain (MBD) protiens in regulation of biological processes in plants.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Review
- Epigenetic gene regulation in plants and its potential applications in crop improvement.Nature reviews. Molecular cell biology · 2025Review
- The generation of novel epialleles in plants: the prospective behind re-shaping the epigenome.Frontiers in plant science · 2025Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Lucia IchinoMolecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID https://orcid.org/0000-0002-0559-1626
Brandon A BooneMolecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID https://orcid.org/0000-0002-6475-8000
Luke StrauskulageDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.
C Jake HarrisDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID https://orcid.org/0000-0001-5120-0377
Gundeep KaurDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0003-3481-9527
Matthew A GladstoneDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID https://orcid.org/0000-0003-1389-7382
Maverick TanDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Suhua FengDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Yasaman Jami-AlahmadiDepartment of Biological Chemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID https://orcid.org/0000-0001-8289-2222
Sascha H DuttkeDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID https://orcid.org/0000-0003-4717-000X
James A WohlschlegelDepartment of Biological Chemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID https://orcid.org/0000-0003-3399-901X
Xiaodong ChengDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID https://orcid.org/0000-0002-6967-6362
Sy ReddingDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.ORCID https://orcid.org/0000-0003-3463-7985
Steven E JacobsenMolecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA. jacobsen@ucla.edu.ORCID https://orcid.org/0000-0001-9483-138X
University of California, Los Angeles · USThe University of Texas MD Anderson Cancer Center · USUniversity of California, San Francisco · USHoward Hughes Medical Institute · USUniversity of California San Diego · US
Funding
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5MUCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7MGENETICS OF EUCARYOTIC AND PROCARYOTIC ORGANISMST32GM007810 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ASHRAFI, KAVEH, NARLIKAR, GEETA J · 1985 to 2020
$15.1MEpigenetic regulations of DNA and histone methylation and deMethylation: Structures and MechanismsR35GM134744 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Xiaodong Cheng · 2020 to 2026
$4.5MProteolytic Control of Iron Metabolism by the Ubiquitin Ligase FBXL5R01GM089778 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOHLSCHLEGEL, JAMES AKIRA · 2010 to 2023
$4.0MEpigenetic gene regulation in ArabidopsisR35GM130272 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JACOBSEN, STEVEN E · 2019 to 2023
$1.6MExploiting Natural Genetic and Organismic Variation to Identify the DNA Motifs Regulating TranscriptionR00GM135515 · NIGMS · WASHINGTON STATE UNIVERSITY · PI DUTTKE, SASCHA H. · 2022 to 2024
$747kExploiting Natural Genetic and Organismic Variation to Identify the DNA Motifs Regulating TranscriptionK99GM135515 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DUTTKE, SASCHA H. · 2020 to 2021
$200kNCI NIH HHS P30 CA016042NIGMS NIH HHS K99 GM135515NIGMS NIH HHS R00 GM135515NIGMS NIH HHS R01 GM089778NIGMS NIH HHS R35 GM130272NIGMS NIH HHS R35 GM134744NIGMS NIH HHS T32 GM007185NIGMS NIH HHS T32 GM007810
Abstract
DNA methylation is associated with transcriptional repression of eukaryotic genes and transposons, but the downstream mechanism of gene silencing is largely unknown. Here we describe two
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